绞股蓝对兔高脂血症与血液流变学影响的研究.pdf

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1、第29卷第15期第三军医大学学报Vol.29No.152007年8月ACTAACADEMIAEMEDICINAEMILITARISTERTIAEAug.20071497文章编号21000-5404(2007)15-1497-03论著绞股蓝对兔高脂血症与血液流变学影响的研究谭华炳(湖北省郧阳医学院附属人民医院医务科十堰442000)提要2目的探讨高脂饲料饲养兔高脂血症和血液流变学异常的相关性及绞股蓝的干预作用0方法40只雄性日本大耳白兔随机数字法分为A组~B组~C组~E组分别喂饲高脂饲料(92.5%标准饲料+2%胆固醇+2%蛋黄+3.5%猪油)+绞股蓝5g/kg~高脂饲料

2、+辛伐他汀5mg/kg~高脂饲料~标准饲料0于实验前和实验后9周检测甘油三酯(TG)~胆固醇(TC)~低密度脂蛋白胆固醇(LDL-C)~高密度脂蛋白胆固醇(~DL-C)~内皮素-1(ET-1)~血液流变学(测全血轴度~血浆轴度~红细胞聚集指数)0观察内皮细胞超微结构0结果①TG~TC~LDL-C~~DL-C2A组~B组~C组饲养后TG~TC~LDL-C明显升高(Pt0.05～0.01)A组和B组TG~TC~LDL-C低于C组(Pt0.05～0.01)A组TG~~DL-C~LDL-C优于B组(Pt0.05～0.01)B组TC优于A组(Pt0.05)9②ET-12A组~B组

3、~C组ET-1水平较饲养前明显上升(Pt0.01)A组~B组显著低于C组(Pt0.01)9③血液流变学2A组~B组~C组全血轴度~血浆轴度~红细胞聚集指数饲养后显著升高(Pt0.05～0.01)A组~B组指标优于C组(Pt0.05)9④内皮细胞超微结构2C组血管内皮细胞细胞质内大量脂滴空泡甚至形成脂舅9A组和B组血管内皮细胞细胞质内偶见小脂滴空泡各种细胞器存在0结论绞股蓝对高脂饲料饲养兔高脂血症和血液流变学异常具有干预作用0关键词2高脂血症9血液流变学9绞股蓝9干预中图法分类号2R285.59R331.19R541.49R589.205文献标识码2AEffectofFi

4、veleafGynostemmaHerbonhyperlipoidemiaandhemorheologicalchan-gesinrabbitsTAN~ua-bing(MedicalDepartmentThepeople's~ospitalofyunyangMedicalCollegeShiyan442000China)Abstract2ObIectiveTostudyeffectofFiveleafGynostemma~erbonhyperlipoidemiaandhemorheologicalchangesinrabbits.MethodsFortyrabbitsw

5、ererandomlydividedasgroupsA(fedwithhighfatfoodplus5g!kgFiveleafGynostemma~erb)B(highfatfoodplus5mg!kgsimvastatin)C(highfatfood)E(standardfeed-stuff).TGTCLDL-C~DL-Cendothelin-1(ET-1)andhemorheologicalindexes(bloodviscosityplasmaviscosityerythrocyteaggregation)werecheckedbeforeexperimentan

6、dat9thweekafterexperiment.Ultramicro-structureofendothelialcellswasobserved.ResultsTGTCandLDL-CofgroupsABandCincreasedgradual-ly.TGTCLDL-CofgroupsAandBwerelowerthanthoseofgroupC(Pt0.05-0.01).TG~DL-CLDL-CofgroupAwerehigherthanthoseofgroupB(Pt0.05-0.01).TCofgroupBwashigherthanthatofgroupA(

7、Pt0.05).ET-1ofgroupsABandCincreasedgradually(Pt0.01)thatofgroupsAandBlowerthangroupC(Pt0.01).Bloodviscositybloodviscosityanderythrocyteaggregationwerehigherthanthosebeforeexperiment(Pt0.05-0.01)thoseofgroupsABhigherthangroupC(Pt0.05).AscomparedwithgroupCendothelialcellinu