对香豆酸对佐剂性关节炎大鼠的抗过氧化作用-论文.pdf

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1、中曲医结合学报2012年8月第lO卷第8期JournalofChineseIntegrativeMedicine，August2012，Vo1．10，No．8Antiper0xidatiVepotentialofP-coumaricacid，acommondclietaryphenoI。iInadjuvant．-iInducedElarthI1ritisiInratsSamuelJoshuaPragasam，VachanaMurunikara，EvanPrinceSabina，Mahabo0bkhanRasoolSchoolofBioSciencesandTechnology，Ve

2、lloreInstituteofTechnologyUniversity，Vellore632014，TamilNadu。IndiaOBJECTIVE：ThepresentstudywasdesignedtoinvestigatetheantiperoxidativepotentialofD—COUmaricacid，acornmortdietaryphenol，inadiuvant-fnducedarthritisinrafs．METHoDS：ArthritiswasinducedbyanintradermaIiniectionof0．1mLcompleteFreund’sadj

3、uvantinthefootpadofrighthindJimbofrats，P—Coumaricacid(1O0mg／kgbodyweight，iniraperitoneaIly)andthereferencedrugindomethacin(3mg／kgbodyweight，iniraperifoneaIIy)wereadministeredtoarthriticratsfor8dfromthe11thdaytothe18thdayafteradiuvantinjection．TheantiperoxidativeeffectofP—COUmaricacidwasinvesti

4、qatedbyassessingchangesin1iPidperoxidationIeveIsandantioxidantstatusin1iver，spIeenandPIasmaoftheadiuvant—inducedarthriticratsfnaddition。radiologicafchangesinhind『imbsofthearthriticratswerealsoanalyzed．RESULTS：P—CoumaricacidtreatmentreversedtheaItered1ipidperoxidationandantioxidantstalusobserve

5、djnarthrjtjcra{stonearnormaJIevels．Soflswe川na，boneerosion，andjojntspacenarrowinanoticedinarthriticratswerefoundtobemitigatedinP—coumaricacid—treatedarthriticrats．CoNCLUSIoN：ThestudyclearlYexhIbitstheantiperoxidativepotentia1ofP—coumariCacidagainstadjuvant—inducedarthritisinrats．KEYWORDS：arthri

6、tis，experimental；coumaricacid；plantextracts；antioxidant；lipidperoxidation；ratsRhcumatoidarthritis(RA)isacommonauto．PrevailingobscurityovertheexactetiologyofRAimmunediseasecharacterizedbychronicinflamhastimeandagainimpededthedevelopmentofmationofsynovialjointsleadingtoprogressivepermanentlyeffe

7、ctiveandsafertherapies．Nevertheless，erosionofcartilageandbonet’．RAhassubstantialnumerousclinicalstudiesaswellaspreclinicalimpactonboththepatientandthesocietyintermsanimalmodelsofRAhavevalidatedanimbalanceofmorbidity．1OSSoffunctionalcapa