凌昌全教授治疗肝癌用药分析【本科临床医学论文设计下载】.doc

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1、临床医学论文•凌昌全教授治疗肝癌用药分析【摘要】在建立门诊肝癌专病病历的基础上，收集经凌昌全教授诊治的552例肝癌患者合计2020张门诊有效处方，使舟频数法总结凌教授的临床常舟药物及其性味归经。运用logistic回归方法分析其辨证用药特点，聚类分析归纳其临床常用对药，结合专家体会对数据结果进行分析。凌教授治疗肝癌临床常用药物以健脾开胃、解毒抗癌和活血化瘀类为主，药性多平、凉，药味主以甘、苦、辛。气虚多选用黄茂、白术、太子参；血虚多用鸡血藤、大枣；阴虚多选用山茱萸、麦门冬；水湿多用翟香、车前子、茯苓皮；实

2、热多选用山梔、黄苓；血瘀多选用桃仁、赤芍；气滞多用郁金、八月札、柴胡。聚类分析共总结出19对临床常用对药。【关键词】凌昌全；肝癌；数学分析，统计；名医经验Abstract:Onthebasisofoutpatients1medicalrecordsconcerningprimarylivercancer(PLC),dataof552patients(with2020effectiveprescriptions)fromtheOutpatientDepartmentofChanghaiHospitaltre

3、ntedbyProfessorLingChangquanwerecollected.Thenature,flavorandmeridiandistributionoftheherbsusedintheprescriptionsweresummarizedbyfrequencymethod,andthefeaturesoftheherbsusedaccordingtosyndromedifferentiationwereanalyzedbylogisticregression.Thecoupleherbsu

4、sedwereanalyzedbyclusteranalysis・Al1thedatawereanalyzedincombinationwiththeexperienceofthespecialist.Itshowedthatmostofthefrequentlyusedherbswereherbsforinvigoratingthespleentopromoteappetite,removingtoxicmaterialstoinhibittumorgrowth,andactivatingbloodci

5、rculationtodissipatebloodstasis・Theseherbsaremostlyofplainorcoolnature,andmainlyofsweet,bitter,oracridtaste.ItalsoshowedthatthemostfrequentlyusedherbsforqideficiencywereAstragalusmembranaceus,Atractylodesmacrocephala,andPseudostellariae;CaulisSpatholobian

6、dChinesejujubeforbloodasthenia;FructusCorniandOphiopogonjaponicusforyindeficiency;Agastacherugosa,SemenPlantaginisandPoriaforwaterdampness;capejasminefruitandbaikalskullcaprootforheatexcess;peachseedandRadixPaeoniaeRubraforbloodstasis;Curcumawenyujin,Akeb

7、iatrifoliataandBupleurumchinenseforqistagnation.Atotalof19pairsofcoupleherbsweresummarizedbytheclusteranalysis.Keywords:LingChangquan;livercancer;dataanalysis,statistical;famousdoctor'sexperience凌昌全教授是国内知名的中医肿瘤专家、上海市名中医和军队第一批中医约“国医名师”。他从20世纪90年代初开始致力于原发性肝

8、癌的中西医结合防治硏究。为总结凌教授治疗肝癌的经验，我们在建立门诊肝癌专病病历的基础上，通过收集和分析其门诊病例资料，对其用药规律进行了初步硏究。1资料与方法1.1资料來源所有病例均來源于第二军医大学长海医院中医科2003年4月〜2006年10月由凌昌全教授门诊诊治的原发性肝癌患者。共收集552例患者2088人次的门诊资料，中药处方2020张。其中男性438例，占79%，女性114例，占21%，男女比例为3.84:1；年龄25