石衫碱-甲对抑郁症患者认知功能疗效的临床研究.doc

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1、石衫碱冲对抑郁症患者认知功能疗效的临床研究【摘要】目的：探讨抑郁症患者认知功能的损害特点及石衫碱-甲对抑郁症患者认知功能的临床疗效。方法：将92例抑郁症患者随机分为研究纽(46例)和对照纽(46例)。研究纽给了石衫碱■甲合并舍曲林治疗，对照组单-•使用舍曲林抗抑郁治疗。两组均治疗12周。采用HAMD、MMSE、词汇流畅测验、联想学习、数字广度测验、相似、领悟及副反应量表，于治疗前、治疗后第1、4、12周末分别对两组进行评定。结果：研究纽•治疗第4周后齐项神经心理学测验与治疗前相比差异有显著性(PvO.05),治疗第12周后与治疗前相比差

2、异有极显著性(P<0・01)。研究组治疗第12周后MMSE、词汇流畅测验、联想学习测验、数字广度测验与对照组相比差异有显著性(PvO・05)o两纽.HAMD在治疗第4周后和治疗第12周后分别与治疗前相比差并均有极显著性(P<0.01)o结论：抑郁症患者认知功能损害与病情严重程度和患者特质有关，石衫碱■甲可改善抑郁症患者特质性认知功能损害，不良反应少而轻。【关键词】石衫碱■甲；抑郁症；认知功能；神经心理学测验TheEffectsofHupei*zine-AontheCognitiveFunctionsinPatientswithDepre

3、ssionLIJian-ping(TheTCMHospitalofLinyi,ShandongLinyi276002,China)Abstract：Objective：Toexplorethecharacteristicsofthecognitivefunctionsofpatientswithdepressionandtheclinicaleftectofhuperzine-Aonthecognitivefunctionsofdepressivepatients.Method:92patientswithdepressionwerer

4、andomlyassignedintotheinterventiongroup(n=46)andthecontrolgroup(n46).Theinterventiongroupwastreatedwithhuperzine-Aandsertraline,whilethecontrolgrouponlywithSertraline,twelveweeksasacourseoftreatment.Bothgroupswereassessedbeforeandafterthefirst,forthandtwelfthweeksoftreat

5、mentwithHAMD,MMSE,Semantic冋uencyTest,AssociateLearning,DigitSpan,SimilarityandComprehension.Result:Thereweresignificantdifferencesofneuropsychologicaltestsintheinterventiongroupaftertheforthweekcomparedwiththatbeforetreatment(P<0-05),andsignificantdifferenceswerefoundaft

6、erthetwelfthweek(P<0.01).ThereweresignificantdifferencesofMMSE,SemanticFluencyTest,AssociateLearningandDigitSpanafterthetwelfthweekbetweentheinterventiongroupandthecOntrolgroup.UtmostdifferencesofHAMDwerefoundbetweenthetwogroupsaftertheforthandtwelfthweekscomparedwiththo

7、sebeforetreatment(P<0.01).Conclusion:Cognitivedysfunctionsofpatientswithdepressionarepositivelycorrelatedwiththeseverityofdepressionandtheattributesofthepatients.Huperzine-Acanimprovethecognitivefunctionsindepressivepatientswithfewsideeffects.Keywords：Huperzine・A；Depress

8、ion；Cognitivefunction；Neuropsychologicaltests许多研究证实，抑郁症患者存在明显的认知功能损害[1〜3],但目前尚无石衫碱■甲对抑郁症患者认知功能治疗方面的研究报道