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时间:2017-12-08
《椎旁注射阿霉素对大鼠肌力和坐骨神经的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·708·逝麻醉堂志2010年8月第26卷第8期JClinAnesthesiol,August2010,Vo1.26,No.8.实验研究.椎旁注射阿霉素对大鼠肌力和坐骨神经的影响李春伟梁慧玲【摘要】目的研究大鼠腰椎旁注射不同浓度阿霉素(ADM)后,大鼠后肢肌力和运动状态的改变及其对坐骨神经的毒性作用。方法8O只大鼠随机均分为四组:0.33ADM组(I组),0.5ADM组(Ⅱ组),1ADM组(Ⅲ组),生理盐水对照组(IV组),分别向右侧腰椎问孑L(L
2、、)注射0.33、0.5、1ADM、生理盐水1
3、0l。术后1、2、4、8周对每组大鼠的右下肢肌力及运动状态进行评价,并于术后2、4周每组随机取2只大鼠进行坐骨神经的组织学观察。结果III组术后l~8周大鼠右下肢出现不同程度的运动障碍,肌力评分明显低于其它三组(P4、;坐骨神经;运动障碍;细胞坏死EffectofadriamycinparavertebralinjectiononmusclepowerandsciaticnerveinratsLC“n—wei,L4ⅣG月-ling.DepartmentofAnesthesiology。YantaiEconomicDevelopmentDistrictHospital。Yanta264006,China[Abstract]ObjectiveTostudytheeffectofadriamycinparavert5、ebralinjectiononmusclepowerandsciaticnerveinrats.MethodsEightyratswererandomlydividedintofourgroupsandinjected10t,1of0.33(groupA),0.5(groupB),1(groupC)ofadriamycinornormalsaline(groupD)intherightsideofL4,L5.Therightlowerextremitymuscleforceandmotions6、tatewereevaluatedonthe1,2谢,4and8weekafterinjection,respectively.Themorphologicchangesofthesciaticnervewereobservedonthe2or4weekafteroperation.RestRtsTheipsolateralposteriorlimbsofratsdisplayedmotordisturbancetodifferentdegreesingroupCfrom1to8weeksand7、thescoresofmuscleforcewereobviouslylowerthanthoseingroupD(P%0.05).AlargenumberofnecroticcellswasfoundinthesciaticnerveingrorupC.Dyskinesiaofposterior1imbswasfoundinseveralratsingroupB.Butobviouspathologicalchangesintheirsciaticnervecellswerefoundingr8、oupB,whichwasnotseeningroupA.IngroupD,afewratsshowedaslightmotorobstacleintheinitialstage,butreturnedtonormallater。andnopathologica1changeswereseeninthesciaticnerves.ConclusionAdriamycin0.33iSasafeconcentrationforclinicalapplication.[Keywords]Adriamy9、cin;Sciaticnerve;Motordisturbance;Cellnecrosis阿霉素(adriamycin,ADM)是一种广泛应用于射不同浓度ADM后,药物在1~8周内能否造成大临床的抗肿瘤药物,属于蒽环类抗生素,具有明显的鼠不可逆转的运动损伤和肌力改变,以及药物的坐细胞毒性和神经毒性等副作用。背根神经节位于椎骨神经毒性作用。间孔内_1],四周被骨性结构包绕,椎旁阻滞能够使药材料与方法物沿着椎间孔进入硬膜外腔,并且主要阻滞穿刺侧神经根。目前临床上应用椎旁注射ADM治疗带状实验材料健
4、;坐骨神经;运动障碍;细胞坏死EffectofadriamycinparavertebralinjectiononmusclepowerandsciaticnerveinratsLC“n—wei,L4ⅣG月-ling.DepartmentofAnesthesiology。YantaiEconomicDevelopmentDistrictHospital。Yanta264006,China[Abstract]ObjectiveTostudytheeffectofadriamycinparavert
5、ebralinjectiononmusclepowerandsciaticnerveinrats.MethodsEightyratswererandomlydividedintofourgroupsandinjected10t,1of0.33(groupA),0.5(groupB),1(groupC)ofadriamycinornormalsaline(groupD)intherightsideofL4,L5.Therightlowerextremitymuscleforceandmotions
6、tatewereevaluatedonthe1,2谢,4and8weekafterinjection,respectively.Themorphologicchangesofthesciaticnervewereobservedonthe2or4weekafteroperation.RestRtsTheipsolateralposteriorlimbsofratsdisplayedmotordisturbancetodifferentdegreesingroupCfrom1to8weeksand
7、thescoresofmuscleforcewereobviouslylowerthanthoseingroupD(P%0.05).AlargenumberofnecroticcellswasfoundinthesciaticnerveingrorupC.Dyskinesiaofposterior1imbswasfoundinseveralratsingroupB.Butobviouspathologicalchangesintheirsciaticnervecellswerefoundingr
8、oupB,whichwasnotseeningroupA.IngroupD,afewratsshowedaslightmotorobstacleintheinitialstage,butreturnedtonormallater。andnopathologica1changeswereseeninthesciaticnerves.ConclusionAdriamycin0.33iSasafeconcentrationforclinicalapplication.[Keywords]Adriamy
9、cin;Sciaticnerve;Motordisturbance;Cellnecrosis阿霉素(adriamycin,ADM)是一种广泛应用于射不同浓度ADM后,药物在1~8周内能否造成大临床的抗肿瘤药物,属于蒽环类抗生素,具有明显的鼠不可逆转的运动损伤和肌力改变,以及药物的坐细胞毒性和神经毒性等副作用。背根神经节位于椎骨神经毒性作用。间孔内_1],四周被骨性结构包绕,椎旁阻滞能够使药材料与方法物沿着椎间孔进入硬膜外腔,并且主要阻滞穿刺侧神经根。目前临床上应用椎旁注射ADM治疗带状实验材料健
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