加强锻炼可降低前列腺癌患者死亡风险.doc

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1、加强锻炼可降低前列腺癌患者死亡风险美国研究人员5日公布一份报告说，他们对前列腺癌患者进行的研究显示，坚持锻炼身体可显著降低该病患者的死亡风险。哈佛大学医学院等机构的研究人员分析了2705名前列腺癌患者确诊后18年间的数据。这些患者每周都记录自己步行、跑步、骑自行车、游泳及其他体育锻炼的时间。分析结果表明，前列腺癌患者只要坚持锻炼，他们的总体生存率都能因此而提高。与每周慢走不超过90分钟的患者相比，每周以正常速度步行或快走超过90分钟的患者，其总体死亡率可下降46％。每周锻炼身体超过3小时的患者死于前列腺癌的风险，比每周锻

2、炼不到一小时的患者低61％。这项研究当天发表在美国《临床肿瘤学杂志》网络版上。科研人员认为，这项研究表明，从事一定强度的体育锻炼可降低前列腺癌扩散的风险，这对前列腺癌患者而言是个“好消息”。原文出处：JournalofClinicalOncology  DOI:10.1200/JCO.2010.31.5226PhysicalActivityandSurvivalAfterProstateCancerDiagnosisintheHealthProfessionalsFollow-UpStudyStaceyA.Kenfiel

3、d,MeirJ.Stampfer,EdwardGiovannucciandJuneM.ChanAbstractPurposeTodeterminewhetherhigherphysicalactivityafterprostatecancer(PCa)diagnosisdecreasesriskofoverallandPCa-specificdeath.PatientsandMethodsWeevaluatedphysicalactivityinrelationtooverallandPCamortalityamong2

4、,705menintheHealthProfessionalsFollow-UpStudydiagnosedwithnonmetastaticPCaobservedfrom1990to2008.ProportionalhazardsmodelswereusedtoevaluatephysicalactivityandtimetooverallandPCa-specificdeath.ResultsAmongmenwholivedatleast4yearsaftertheirpostdiagnosisphysicalact

5、ivityassessment,wedocumented548deaths,20%ofwhichwerearesultofPCa.Inmultivariableanalysis,menwhowerephysicallyactivehadlowerriskofall-causemortality(Ptrend<.001)andPCamortality(Ptrend=.04).Bothnonvigorousactivityandvigorousactivitywereassociatedwithsignificantlylo

6、weroverallmortality.Thosewhowalked≥90minutesperweekatanormaltoverybriskpacehada46%lowerriskofall-causemortality(hazardratio[HR]0.54;95%CI,0.41to0.71)comparedwithshorterdurationsataneasywalkingpace.Menwith≥3hoursperweekofvigorousactivityhada49%lowerriskofall-cause

7、mortality(HR,0.51;95%CI,0.36to0.72).ForPCa-specificmortality,briskwalkingatlongerdurationswassuggestivelyinversebutnotstatisticallysignificant.Menwith≥3hoursperweekofvigorousactivityhada61%lowerriskofPCadeath(HR,0.39,95%CI,0.18to0.84;P=.03)comparedwithmenwithless

8、than1hourperweekofvigorousactivity.Menexercisingvigorouslybeforeandafterdiagnosishadthelowestrisk.ConclusionInmenwithPCa,physicalactivitywasassociatedwithlower