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1、DISTRIBUTIONOFTHETOTALNUMBEROFPATIENTS(N=19125)BYSOLIDTUMORTYPENumberof%¨BREASTCARCINOMA............................….……….(44%)¨NEUROBLASTOMA...........................……....................(13%)¨GERMCELLTUMORS.........................………...............(10%)¨EWING’SSARCOMA......
2、......................……...................(6%)¨CENTRALNERVOUSSYSTEMTUMORS....................(5%)¨SOFTTISSUESSARCOMA.......................…...………(5%)¨OVARIANCARCINOMA....................….....….........…...(5%)¨SMALLCELLLUNGCANCER...............….......……...(2%)¨P.N.E.T.......
3、......................……..........................……..(2%)¨OSTEOSARCOMA...........................……........................(1%)¨WILMS’TUMORS...........................…….......................(1%)¨OTHERTUMORS…………………………....................patients83552404201110981054955880437367
4、2652241075(6%)-ALLDISEASES-1987198819891990199119921993199419951996199719981999200015%12%18%13%10%7%6%5%4%3%2%2%at100daysfromgraftSOLIDTUMORS:TOTALTOXICDEATHS01002003004005006007001988199019921994199619982000adjuvantmetastaticSOLIDTUMORS:ADJUVANTvsMETASTATICNUMBEROFPATIENTSPERYE
5、ARGONADALGERMCELLTUMORSStatusatgraft:SensitiveRelapseN=148Mediansurvival30monthsMonthsfromgraft908478726660544842363024181260OverallSurvival1,0,9,8,7,6,5,4,3,2,10,0OVARIANCARCINOMAMonthsfromgraft847260483624120ProgressionfreeSurvival1,0,9,8,7,6,5,4,3,2,10,0CR:N=295MedianPFS27mon
6、thsOthers:N=478MedianPFS10monthsCROthersp=0.0001StatusatgraftCRvsothersEWING`sSarcoma+PNETStatusatgraft:CRvsothersMonthsfromgraft78726660544842363024181260OverallSurvival,9,8,7,6,5,4,3,2,10,01,0CR:Mediansurvival64monthsN=626Others:Mediansurvival15monthsN=787CROthersp=0.0001METAS
7、TATICBREASTCARCINOMAEstrogenpositivevsnegativeMonthsfromgraft160140120100806040200Overallsurvival1,0,9,8,7,6,5,4,3,2,10,0p=0,0401Median42monthsN=526estrogenpositiveMedian34monthsN=450estrogennegativeMonthsfromgraft%p(DFS)=0.0005Adjuvantpatients:<10vs>10positivenodes>10N=625<10N=
8、309MedianDFS=69mSolidTumours:AdjuvantPatients<1
