孟鲁司特联合沙美特罗替卡松治疗轻中度支气管哮喘临床观察.doc

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1、孟鲁司特联合沙美特罗替卡松治疗轻中度支气管哮喘临床观察［摘要］目的观察孟鲁司特联合吸入沙美特罗替卡松(舒利迭)治疗轻中度支气管哮喘的临床疗效及安全性。方法66例支气管哮喘患者随机分为实验组35例和对照组31例。实验组口服孟鲁司特10mg,每晚1次顿服，沙美特罗替卡松每日2次吸入；对照组吸入沙美特罗替卡松，每日2次。观察两组患者哮喘临床症状及肺功能改善情况，记录药物不良反应。结果实验组总有效率为91.4%(32/35),对照组总有效率为83.9%(26/31),两组间比较差异有统计学意义(P<0.05)；实验组与对照组治疗前后临床症状及肺功能指

2、标有明显改善，ACT评分显著提高，两组对比差异有统计学意义(P<0.05)；实验组治疗后临床症状缓解及消失时间均短于对照组，差异有统计学意义(P<0.05)。两组患者在治疗期间均无严重不良反应。结论孟鲁司特联合沙美特罗替卡松治疗轻中度哮喘的疗效优于单独使用沙美特罗替卡松，联合使用能更迅速地改善患者肺功能和临床症状，是安全有效的治疗方案。［关键词］支气管哮喘；孟鲁司特；沙美特罗替卡松；肺功能［中图分类号］R562.2+5［文献标识码］A［文章编号］1674-4721(2012)07(c)-0057-02Clinicalobservationof

3、montelukastcombinedwithseretideintreatmentofmildandmoderatedegreebronchialasthmaGUYingLUHuiyuGAOXiaoyanLINWenDepartmentofRespiratoryMedicine,TaizhouPeople，sHospitalinJiangsuProvince,Taizhou225300,China[Abstract]ObjectiveToobservetheclinicalefficacyandsafetyofmontelukastcomb

4、inedwithseretide(salmeteyolandfluticas)intreatmentofmildandmoderatedegreebronchialasthma・MethodsSixtysixpatientswithmildormoderatedegreebronchialasthmaweredividedintotwogroupsrandomly.Theexperimentgroup(n=35)weregivenmontelukast10mg/dandseretideaccuhalertwiceaday.Thecontrol

5、group(n=31)weregivenseretideaccuhalertwiceaday.Theimprovementoftheclinicalsymptoms,thechangeoflungfunctionandtheadversedrugreactionintwogroupswereobserved・ResultsThetotaleffectiverateinexperimentgroupwas91.4%(32/35),incontrolgroupwas83.9%(26/31)・Therewasstatisticaldifferenc

6、ebetweenthem(P<0.05).Inthefollow-upperiod,theclinicalsymptomsandlungfunctionsignifiesntlyimproved,thesymptomscore(ACT)intheexperimentgroupwassignificantlyhigherthanthatinthecontrolgroup.Therewerestatisticaldifferencesbetweentwogroups(P<0・05)・Thetimeofclinicalsymptomsremissi

7、oninexperimentgroupwasshorteTthanthatofthecontrolgroup,therewasstatisticaldifferencebetweenthem(P<0.05).Nosevereadverseeventsoccurredintwogroups・ConclusionTheclinicalsymptomsandlungfunctionimprovementappearsmorerapidlyintreatmentbymontelukastcombinedwithseretidethanbysereti

8、deonly.Montelukastcombinedwithseretideiseffectiveandsafeinthetreatmentofasthma.[Ke