[精品]乳腺癌患者血清抵抗素和Hs-CRP检测的临床意义.doc

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1、乳腺癌患者血清抵抗素和Hs-CRP检测的临床意义乳腺癌患者血清抵抗素和Hs-CRP检测的临床意义【摘耍】目的探讨乳腺癌患者血清抵抗素和高敏C反应蛋白(Hs-CRP)含量的变化及其临床意义｡方法选择病理确诊的乳腺癌住院患者77例(转移者53例､未转移者24例)､乳腺增生组40例和健康对照组36例作为对照组，术前抽取空腹静脉血并取血清,ELISA法测定血清抵抗索含量，以及采用免疫比浊法对血Hs-CRP进行测定｡结果乳腺癌转移患者血清抵抗素和Hs-CRP含量明显高于未转移患者、乳腺增生患者以及健康对照组血清屮的含量；同时

2、乳腺癌患者TNM分期II､III、IV期血清抵抗素和Hs-CRP含量均高于T期血清抵抗素和Hs-CRP含量(P<0.01),而II､III、IV期之间血清抵抗素和Hs-CRP含量无显著性差异(P>0.05)结论乳腺癌患者血清抵抗素和Hs-CRP含量升高，抵抗素和Hs-CRP含量的升高程度在预测乳腺癌转移和预后方面具有指导意义｡【关键词】乳腺癌抵抗素高敏C反应蛋白中国图分类号:R730.26文献标识码M文章编号:1005-0515(2010)08-066-03Theclinicalsignificanceofdeterminati

3、onofresistinandhigh-sensitiveC-reactiveproteinforthepatientsofbreastcancer・[Abstract]Object!veToexploretheclinicalsignificanceofdeterminationofresistinandHs~CRPforthepatientsofbreastcancer・MethodsAccordingtometastasisofcarcinomaornot,77patientsofbreastcancerwhowerediagnosedbypathologywer

4、edividedintothemetastasisgroupwith53patientsandtheno-metastasisgroupwith24patients,36normalwomenwerecontrolgroup・Thefastingvenousbloodwastakenfromallsubjects・Andserumresistinconcentrationswasdeterminedwithenzymelinkedimmunosorbentassay(ELISA),Hs~CRPwasdeterminedbyratenephelometryimmunoas

5、say.ResultsSerumresistinconcentrationsinthemetastasisgroup(2.70±1.50mg/L)werelowerthanthoseintheno-metastasisgroup(4.51+1.98mg/L)(卩〈0.01),whichwerelowerinthecontrolgroup(7.29±2.06mg/L)(P<0.01).AndSerumresistininpatientsofTNMII(2.81±1.65mg/L),III(2.66±1.58mg/L)andIV(2.32+1.41mg/L)stageofb

6、reastcancerwerelowerthanthatinpatientsofTNMI(4.46±2.04mg/L)stage,butadiponectinconcentrationsshowednotsignificantdiffereneeinpatientsofTNMII､IIIandIVstage(P>0.05)・ConclusionSerumresistinconcentrationsinpatientsofbreastcancerwerelowerthaninnormalwomen,andtheserumresistinsteppingdow

7、nmaypredictmetastasisandprognosisofbreastcancer・[KeywordsjBreastcancerResistinHigh-sensitiveC-reactiveprotein(Hs-CRP)乳腺癌是女性最常见的恶性肿瘤，发病率为10%〜近年来我国乳腺癌的发病率明显上升，从20世纪90年代初期就已成为女性中的第一位恶性肿瘤,乳腺癌的发病年龄以40〜60岁的女性为最多见。抵抗素(Resistin)是口色脂肪细胞分泌的细胞因子，这种细胞因子不仅对调节胰岛素敏感性和糖脂代谢发挥着重要作用，参与了肥胖和高