强直性脊柱炎患者脊柱骨赘的分布及其与病程的关系-论文.pdf

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1、第36卷第l期中山大学学报(医学科学版)Vol_36No．12015年1月JOURNALOFSUNYAT—SENUNIVERSITY(MEDICALSCIENCES)Jan．2015强直性脊柱炎患者脊柱骨赘的分布及其与病程的关系涂柳丹，张萍萍，魏秋静，古洁若(中山大学附属第三医院风湿免疫科，广东广州510630)摘要：【目的】探讨强直性脊柱炎患者脊柱韧带骨赘的分布及其与病程的关系。【方法】于2013—2014年符合1984年纽约标准的强直性脊柱炎患者纳入本研究。所有患者均进行了骶髂关节、颈胸腰椎正侧位x线片等

2、相关检查。我们分析了相应的临床资料、实验室检查结果和影像学资料。【结果】82名强直性脊柱炎患者的平均年龄为(27．4±7．7)岁，平均病程为(6．1±6．1)年，65．85％的患者有超过一个的韧带骨赘。腰椎、胸椎和颈椎受累比例分别为51．22％、0．08％和29．26％。腰椎骨赘比颈椎、胸椎骨赘更为多见。有骨赘组的平均病程明显长于无骨赘组(P=0．001)。随着病程增加，全脊柱平均韧带骨赘数随之增多。【结论】强直性脊柱炎患者脊柱韧带骨赘的分布以腰椎多见，疾病病程的长短与脊柱骨赘数正相关，与疾病炎症指标无关。关

3、键词：强直性脊柱炎：韧带骨赘：病程中图分类号：R593．23文献标志码：A文章编号：1672—3554(2015)01—0024—04DistributionofSpinalSyndesmophytesandtheRelationshipbetweenSyndesmophytesandDiseaseDurationofAnkylosingSpondylitisTULiu—dan，ZHANGPing—ping，WEIQiu—jing，GUJie一1％10(DepartmentofRheumatology，Thi

4、rdAffiliatedHospitalofSunYat—senUniversity，Guangzhou510630，China)Correspondingauthor：GUJie—FUO，E—mail：gujieruo@163．comAbstract：【Objective】Toevaluatethedistributionofspinalsyndesmophytesandtoexploretherelationshipbetweenspinalsyndesmophytesanddiseaseduration

5、ofankylosingspondylitis．【Methods】Patientswhowerediagnosedwithankylosingspondylitisbetween2013and2014accordingtothe1984revisedNewYorkcriteriawereincludedintoourstudy．AllpatientshadreceivedX—rayofsa'croiliacjoint，cervical，thoracicandlumbervertebra．Weanalyzedt

6、heirclinicaldata，laboratoryexaminationandradiographyresults．【Results】Atotalof82ankylosingspondylitispatientswereincludedwithameanageof27．4±7．7yearsoldandaaveragediseasedurationof6．1-+6．1years．65．85％oftotalpatientshadsyndesmophytes．Theproportionoflumberthora

7、cicandcervical，vertebrainvolvementwere51．22％，0．08％，and29．26％，respectively．Syndesmophytesoflumbervertebraweremorecommonthanthoracicandcervicalvertebra．Thediseasedurationofsyndesmophytesgroupwaslongerthangroupwithoutsyndesmophytes(P0．001)．Theaveragenumberofsy

8、ndesmophytesriseswiththeincreaseofdiseaseduration．【Conclusion】Thedistributionofspinalsyndesmophytesofankylosingspondylitiswascommonlyseeninlumbervertebra．Thelengthofdiseasedurationwasassociatedwiththen