归芍地黄汤联合经瞳孔温热疗法抑制CNV的初步实验研究-论文.pdf

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1、医眼·249·实验研究·归芍地黄汤联合经瞳孔温热疗法抑制CNV的初步实验研究刘安曹明芳金威尔【摘要】目的探讨归芍地黄汤、经瞳孔温热疗法(rITrr)治疗脉络膜新生血管的作用。方法建立CNV动物模型．运用归芍地黄汤及1]治疗，设立正常对照组、阴性对照组、1][YI’治疗组、中药治疗组、中药联合Trr治疗组．于造模后4周、8周行FFA检查及OCT检查，于造模后8周行HE及电镜检查。结果造模后4周．FFA检查可见CNV的渗漏，OCT检查可见CNV。造模后8周，FFA检查显示中药联合rr治疗组CNV渗漏减轻最显著，OC

2、T检查显示中药联合，r]治疗纽CNV消退最明显，HE、电镜检查结果显示中药联合T兀’治疗组CNV数目减少最明显。结论T]盯、中药均可以使半导体激光诱导的兔CNV动物模型的CNV消退．综合来看，中药联合肿治疗组效果最为显著。【关键词】脉络膜；新生血管；经瞳孔温热疗法；中药中图分类号：R285．5文献标识码：A文章编号：1002-4379{2008)05—0249—04PreliminaryExperimentalStudyonExudativeSenileMacularDegenerationTreatedbyG

3、uishaodi-huangtang(归芍地黄汤)andTranspupillaryThermotherapy．LIUA凡，CA0MinJang,JINWeier．Departmento}Ophthalmology，TheAfiliatedPeopleSHospitalofFCollegeoftraditionalChinesemedicine，Fuzhou350004，China【Abstract】ObjectPreliminaryStudyonexudativesenilemaeulardegenerati

4、ontreatedbyguishaodihuang—tang(9z芍地黄汤1andtranspupillarythermotherapy．MethodsInducechoroidalneovascularizatrionanimalmodeltreatedwithguishaodihuangtang(归芍地黄汤)andtranspupillarythermotherapy．Divideanimalsintofivegroups：normalcontrol，negativecontrol，transpupilla

5、rythermotherapytreatmentgroup，traditionalChinesemedicinetreat—mentgroupandcombinedtreatmentgroup．Fundusfluoreseeinangiographyandopticalcoherencetomographyex—aminationsoceu~edweeks4and8．Hematoxylineosinstainandtransmissionelectronmicroscopyweremadeonweeks8．Re

6、sultsChoroidalneovascularizatrionwasconfirmedbyfundusfluoresceinangiographyandopticalCO—herencetomographyonweed4．Throughfundusfluoresceinangiography，opticalcoherencetomography，hema—toxylineosinstainandtransmissionelectronmicroscopy，thebestcurativeeffectgroup

7、iscombinedtreatmentgroup．ConclusionsTranspupillarythermotherapyandtraditionalChinesemedicinecansubsidisechoroidalneo—vascularizatrion．Thebestcurativeeffectgroupiscombinedtreatmentgroup．【Keywords】Choroidalneovascularizatrion；Transpupillarythermotherapy；Tradit

8、ionalChinesemedicinetherapy；Fundusfluoresceinangiography；Opticalcoherencetomography渗出型年龄相关性黄斑变性(exudativesenileeration，AMD)的CNV

9、2，但难以完全破坏活动性极maculardegeneration，ESMD)的治疗方法主要围绕着强的新生血管，亦不能阻止新的新生血管