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1、临床耳鼻咽喉科杂志2000年2月第14卷第2期·55·变应性鼻炎与气道高反应的关系1111马瑞琴 曲百胜 刘瑞玲 李砚伟 摘要 目的:探讨变应性鼻炎与气道高反应性的相关性。方法:用1∶100(wöv)蒿属花粉对50例变应性鼻炎和20例正常者做支气管激发试验,分别测定两组第1秒用力呼气量(FEV1);测血清中嗜酸性粒细胞阳离子蛋白(ECP)。结果:支气管激发试验前,两组支气管均无症状,鼻炎组FEV1为(70±20)%,对照组为(85.6±8.9)%,两组有显著性差异(P<0.01);支气管激发后,鼻炎组中23例胸部有紧迫
2、感,10例有哮鸣,5例有喘息,12例无症状,激发阳性率为76%。对照组均无支气管症状。激发后鼻炎组FEV1为(60±20)%,对照组为(85.6±8.9)%,两组有显著性差异(P<0.05)。鼻炎组ECP为(30.37±18.92)LgöL,对照组为(5.24±3.23)LgöL,两组有显著性差异(P<0.05)。结论:变应性鼻炎不仅鼻粘膜有变态反应所致的慢性炎症,而且大部分气道也有慢性炎症反应而导致气道高反应性。关键词 变应性鼻炎 嗜酸性粒细胞阳离子蛋白 支气管激发试验 支气管高反应性Studyontherelatio
3、nshipbetweenallergicrhinitisandairwayhyperresponsiveness1111MARui2qinQUBai2shengLIURui2lingLIYan2wei1(DepartmentofOtolaryngologyandAllergy,GeneralHospitalofTianjinMedicalUniversity,Tianjin300052)AbstractObjective:Inordertostudytherelationshipbetweenallergicrhinit
4、isandairwayhyperrespon-siveness.Method:Eachofthemwereseparatelyengagedskintestwithantigen.All50patientshadintenseposi2tivereactiontoartemisiapollen(6～7),butallcontrolswerenegative.Weconductedbronchialprovocationtest(BPT)with1∶100(wöv)artemisiapollen.Beforeandafte
5、rBPT,weseparatelytestedtheforcedexpiratoryvol2umeinfirstsecond(FEV1)whichrepresentedventilativefunctionandeosinophilcationicprotein(ECP)intheirserum.Result:BeforeBPT,50patientsand20normalcontrolshadnotracheasymptoms.FEV1of50patientsis(70±20)%,thatofnormalcontrols
6、is(85.6±8.9)%(P<0.001).AfterBPT,in50patients,23casesfeltcon2strictioninthechest,10caseshadwheezes,5caseshadasthma,12caseshadnosymptoms.Atthesametime,allofnormalcontrolshadnosymptoms.AfterBPT,FEV1of50patientsis(60±20)%,thatofnormalcontrolswas(85.6±8.9)%(P<0.05),EC
7、Pofpatientswas(30.37±18.92)LgöL,thatofcontrolswas(5.245±3.228)LgöL(P<0.05).Conclusion:Patientswithallergicrhinitisnotonlyhavechronicinflammationintheirnosemu2coseathatresultsfromallergicreact,butalsohavechronicinflammationinbronchuswhichleadstoAHR.Theresultsrevea
8、lthatmostpatientswithallergicrhinitishaveAHR(76%).KeywordsAllergicrhinitisEosinophilcationicproteinBronchialprovocationtestBronchialhyperreac2tivity 实验表明,气道高反
