冠心病中医证型与血脂反应蛋白及同型半胱氨酸相关性研.pdf

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1、辽宁中医杂志2013年第40卷第4期·707·冠心病中医证型与血脂、C－反应蛋白及同型半胱氨酸相关性研究111121王恒和，张妍，王贤良，牛子长，张富赓，朱亚萍(1.天津中医药大学第一附属医院心血管科，天津300193;2.天津市环湖医院药剂科，天津300060)摘要:目的:探讨冠心病(CHD)中医辨证分型与血脂、C－反应蛋白(CRP))及同型半胱氨酸(Hcy)水平的关系，为冠心病中医辨证分型提供客观化依据。方法:220例冠心病患者中医辨证为气虚血瘀证、气阴两虚、气滞血瘀、痰阻心脉、心血瘀阻、阳气虚衰;35例健康人作为对照组，分别检测血脂四项、血清CRP及Hcy水平，分析各指

2、标与中医证型之间的相关性。结果:(1)证型分布呈现痰阻心脉＞气虚血瘀＞气阴两虚＞心血瘀阻＞气滞血瘀＞阳气虚衰的趋势。(2)血清脂质水平:总胆固醇、甘油三酯痰阻心脉证＞气滞血瘀证＞气虚血瘀证＞心血瘀阻证＞气阴两虚证＞阳气虚衰证;低密度脂蛋白痰阻心脉证＞气滞血瘀证＞心血瘀阻证＞气虚血瘀证＞气阴两虚证＞阳气虚衰证。(3)冠心病组CRP水平明显高于正常对照组(P＜0.05)，各证型组间CRP水平呈瘀阻心脉证＞心血瘀阻证＞气滞血瘀证＞气阴两虚证＞气虚血瘀证＞阳气虚衰证。(4)Hcy水平心血瘀阻证＞瘀阻心脉证＞气滞血瘀证＞气虚血瘀证＞气阴两虚证＞阳气虚衰证。结论:血清脂质、CRP、Hcy

3、水平与冠心病中医证型存在相关性，可作为冠心病中医辨证分型辅助诊断的客观指标。关键词:冠心病;辨证分型;血脂;C反应蛋白;同型半胱氨酸中图分类号:R541．4文献标志码:B文章编号:1000－1719(2013)04－0707－04ResearchonCorrelationbetweenTraditionalChineseMedicineSyndromeTypesofCHDandBloodLipids，CRPandHcy111121WANGHenghe，ZHANGYan，WANGXianliang，NIUZichang，ZHANGFugeng，ZHUYaping(1.Depar

4、tmentofCardiology，TianjinUniversityofTraditionalChineseMedicine，Tianjin300193，China;2.TianjinHuanhuHospital，Tianjin300060，China)Abstract:Objective:InvestigationonthecorrelationbetweentraditionalChinesemedicine(TCM)syndrometypesofcoronaryheartdisease(CHD)andbloodlipids，C－reactiveprotein(CRP)

5、andhomocysteine(Hcy)levelswascarriedon．Thisistopro-videanobjectivebasistothedifferentiationofTCMsyndrometypesofCHD．Methods:Thestudyrecruited220CHDpatientsand35healthycontrolsubjects．TheTCMsyndrometypesoftheCHDpatientsincludedQideficiencyandbloodstasis，QiandYinde-ficiency，Qistagnationandbloo

6、dstasis，phlegmstasis，heartbloodstasisandYangdeficiency．Allsubjectsweretestedforbloodlipidslevel，serumCRPandHcylevelsandtheindiceswereanalyzedforitscorrelationswiththeTCMsyndrometypes．Results:(1)Thesyndromedistributionpresentedthetrendofphlegmstasissyndrome＞Qideficiencyandbloodstasissyndrome

7、＞QiandYindeficiencysyndrome＞heartbloodstasissyndrome＞Qistagnationandbloodstasissyndrome＞Yangdeficiencysyndrome．(2)Thelevelsofserumlipid:totalcholesterol，triglyceride:phlegmstasissyndrome＞Qistagnationandbloodstasissyndrome＞Qideficiencyandbloodstasissyndro