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时间:2017-12-07
《不同促排卵方案在卵巢功能减退患者中的有效性观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、·28·成都医学院学报2014年第9卷第1期JournalofChengduMedicalCollege,2014,Vo1.9,No.1网络出版地址:http://www.cnki.net/kcms/detail/51.1705.R.2O140222.1023.001.htmldoi:10.3969/j.issn.1674—2257.2014.O1.009·临床报道·不同促排卵方案在卵巢功能减退患者中的有效性观察陈颖,扎西(成都市妇女儿童中心医院妇产科,成都610031)【摘要】目的比较促性腺激素释放激素激动剂(GnRH—a)长方案和促性腺激素释放激素抑制剂(GnRH—A)方案对卵
2、巢功能减退患者促排卵效果和f临床妊娠的影响,为促排卵优选方案提供理论依据。方法选取符合标准的患者8O例,随机分为观察组(GnRH—A方案)和对照组(GnRH—a长方案)各4O例,比较二组治疗效果。结果两组患者hCGEt血清雌二醇(E2)、黄体生成素(IH)及孕酮(P)水平比较,差异无统计学意义(P>0.05);对照组Gn用药天数及用药量明显多于观察组,差异有统计学意义(P<0.05)。观察组临床妊娠率高于对照组,差异有统计学意义(P<0.05);对照组取卵数及受精数低于观察组,差异有统计学意义(P%0.05)。结论GnRH—A方案可提高患者临床妊娠率,可能是卵巢功能减退患者一种较好
3、的促排卯治疗方法。【关键词】卵巢功能减退;控制性促排卵;促性腺激素释放激素激动剂;促性腺激素释放激素抑制剂【中图分类号】R714.8【文献标志码】BObservationonTheEffectivenessofDifferentOvarianStimulationMethodsinHypovariaPatientsCHENYing,ZHAXi(DepartmentoJ、ObstetricsandGynecology.TheWomenandChildren'sHospitaloJChengdu.Chengdu6lOOl5.China)[Abstract]ObjectiveTocomp
4、aretheeffectsofgonadotropinreleasinghormoneagonist(GnRH—a)andgonadotropinreleasinghormoneinhibitor(GnRH—A)ontheovarianstimulationoutcomeandclinicalpregnancyinhypovariapatients,andtOprovidetheoreticfoundationsforoptimizingmethodforovarianstimulation.MethodsEightyeligiblepatientswereselectedandr
5、andomlydividedintoobservationgroupandcontrolgroup,40patientseach;theobservationgroupusedGnRH—A,whilethecontrolgroupusedGnRH—a,andthetherapeuticeffectsofthetwogroupswerecompared.ResultsThedifferencesinserumestradiol(E2),luteinizinghormone(IH)andprogesterone(P)levelsbetweenthepatientsofthetwogro
6、upswerestatisticallyinsignificant(P>0.05);butthemedicationdurationanddrugconsumptionofthepatientsofthecontrolgroupweresignificantlymorethanthoseoftheobservationgroup,andthedifferenceswerestatisticallysignificant(尸<0.05).Theclinicalpregnancyrateofthepatientsoftheobservationgroupwashigherthantha
7、tofthecontrolgroup,andthedifferencewasstatisticallysignificant(P<0.05);thetakeneggnumberandfertilizedeggnumberofthepatientsinthecontrolgroupwereCowerthanthoseoftheobservationgroup,andthedifferenceswerestatisticallysignificant(P
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