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1、XX大学毕业论文血清脂联素水平与肥胖和性别的关系2014年6月25日血清脂联素水平与肥胖和性别的关系【关键词】血清脂联素,【摘要】FI的研究天津地区人群血清脂联素(adiponectin)水平与年龄、性别、体脂(FAT%)、腰臀比(WHR)及体重指数(BMI)的关系。方法以我院132例健康体检者作为研究对象,据体重指数分为超重或肥胖组79例,正常体重组53例,测定受试者的体重指数、腰臀比及血浆胆
2、古I醇和II油三酯,并采用放免法测定空腹状态下的血清脂联素水平。结果不论性别,超重或肥胖组的血清脂联素水平均较正常体重组显著降低〔男(11.71±4.22)mg/Lvs(16.28±5.00)
3、mg/L,P=0.000;女(14.80±5.25)mg/Lvs(19.56±5.74)mg/L,P=0.001);不论体重,男性血清脂联素水平均较女性显著降低(超重或肥胖组(14.80±5.25)mg/Lvs(11・71±4.22)mg/L,P=0.005);正常体重组(19.56±5.74)mg/Lvs(16.28±5.00)mg/L,P=0.033)o血清脂联素与BML腰臀比、腰围(YW)及FAT%呈显著负相关,与血脂胆固醇(TC)水平无相关性,与甘油三酣(TG)呈负相关。在本年龄段屮,与年龄关系不大。多元逐步冋归分析表明,血清脂联素与BMLWHR呈高度负相关(男r2=0.639
4、,P=0・000;女r2=0.487,P=0.000)o结论血清脂联素水平存在性别差界;与反映肥胖程度的指标BMRWHR呈显著负相关。因此肥胖是影响该脂肪因子的重耍因素。关键词血清脂联素体重指数腰臀比肥胖Relationshipbehveenserumadiponectinconcentrationandobesityaswellassexuality[Abstract]ObjectiveTostudytherelationshipbetweenserumadiponectinandage,genderbodyfat,waisthipratio(WHR),bodymassindex(B
5、MI)andbloodlipidinTianjinpopulations.Methods79and53healthyobjectswererespectivelyfallenintoovcrwcight/obcscgroup(BMI>25kg/m2)andnormal-weightedgroup(BMI25kg/m2).FastingserumadiponectinwasdetectedbyRIA,meanwhileBMI.WHRandbloodlipidwerealsomeasured.ResultsInbothmenandwomen,theconcentrationofscruma
6、diponectininoverweightobesegroupwassignificantlylowerthanthatinnormal-weightedgroup,[(11.71±4.22)mg/Lvs(16.28±5.00)mg/L,P=0.000inmen;(14.80±5.25)mg/Lvs(19.56±5.74)mg/L,P=0.001inwomen].Moreover,Inbothoverweight,obeseornormalweightedsubjects,theserumadiponectinlevelinwomenwashighterthanthatofmen.[
7、overweight/obesegroup(14.80±5.25)mg/Lvs(11.71±4.22)mg/L,P=0.005;normal-weightedgroup(19.56±5.74)mg/Lvs(16.28±5.00)mg/L,P=0.033].SerumadiponectinconcentrationwasnegativelycorrelatedwithBMI、WHRand%bodyfatsignificanily.Adiponetinwasnotsignificantlycorrelatedwithageinstudy.Multipleregressionanalysis
8、showedBMIandWHRwerethemainindependentrelativefactorsinfluencingserumadiponectinconcentrationinbothmenandwomen(allP0.05).ConclusionAdiponetinlevelisdifferentbetweenmaleandfemale.Obesityisanimportantinfluentialfactortoadiponec