BENZOYL PEROXIDE-过氧化苯甲酰.pdf

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1、BENZOYLPEROXIDErdPreparedatthe63JECFA(2004),publishedinFNP52Add12(2004)supersedingspecificationspreparedatthe55thJECFA(2000)andpublishedinFNP52Add8(2000).Treatmentofwheywithbenzoylperoxideatardmaximumconcentrationof100mg/kgdoesnotposeasafetyconcern(63JECFA,2004).S

2、YNONYMSBenzoylsuperoxide,INSNo.928DEFINITIONBenzoylperoxideismanufacturedbythereactionofbenzoylchloride,sodiumhydroxideandhydrogenperoxide.ChemicalnameDibenzoylperoxideC.A.S.number94-36-0ChemicalformulaC14H10O4StructuralformulaFormulaweight242.23AssayNotlessthan96

3、.0%DESCRIPTIONColourless,crystallinesolidhavingafaintodourofbenzaldehyde.Caution:Benzoylperoxide,especiallyinthedryform,isadangerous,highlyreactive,oxidizingmaterialandhasbeenknowntoexplodespontaneouslyFUNCTIONALUSESBleachingagentCHARACTERISTICSIDENTIFICATIONSolub

4、ility(Vol.4)Insolubleinwater,slightlysolubleinethanolandsolubleinether.Meltingrange(Vol.4)103-106°withdecompositionDecompositiontobenzoicTo0.5gofthesampleadd50mlof0.5Nethanolicpotassiumhydroxide,heatacidgraduallytoboilingandcontinueboilingfor15min.Coolanddilutewit

5、h200mlofwater.Addsufficient0.5Nhydrochloricacidtomakestronglyacidicandextractwithether.Drytheethersolutionoveranhydroussodiumsulfate,andthenevaporatetodrynessonasteambath.Thebenzoicacidsoobtainedmeltsbetween121°and123°.PURITYLead(Vol.4)Notmorethan2mg/kgDetermineus

6、inganatomicabsorptiontechniqueappropriatetothespecifiedlevel.TheselectionofsamplesizeandmethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescribedinVolume4,"InstrumentalMethods".METHODOFASSAYDissolveabout250mgofthesample,accuratelyweighed,in15mlofaceto

7、neina100-mlglass-stopperedbottle.Add3mlof50%(w/v)potassiumiodidesolutionandswirlfor1min.Titrateimmediatelywith0.1Nsodiumthiosulfate(withoutadditionofstarchasanindicator).Eachmlof0.1Nsodiumthiosulfateisequivalentto12.11mgofC14H10O4.