BUTYLATED HYDROXYANISOLE-丁基羟基茴香醚(BHA).pdf

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1、BUTYLATEDHYDROXYANISOLEPreparedatthe33rdJECFA(1988),publishedinFNP38(1988)andinFNP52(1992).Metalsandarsenicspecificationsrevisedatthe61stJECFA(2003)AnADIof0-0.5mg/kgbwwasestablishedatthe33rdJECFA(1988)SYNONYMSBHA;INSNo.320DEFINITIONChemicalnames3-Tertiary-butyl-4-hydroxyanisole,amixture

2、of3-and2-tertiary-butyl-4-hydroxyanisoleC.A.S.number25013-16-5ChemicalformulaC11H1602StructuralformulaFormulaweight180.25AssayNotlessthan98.5%ofC11H1602andnotlessthan85%of3-tertiary-butyl-4-hydroxyanisoleDESCRIPTIONWhiteorslightlyyellowcrystalsorwaxysolid,withafaintcharacteristicodourFU

3、NCTIONALUSESAntioxidantCHARACTERISTICSIDENTIFICATIONSolubility(Vol.4)Insolubleinwater;freelysolubleinethanolandpropane-1,2-diolColourreactionTo5mlofa1in10,000solutionofthesamplein72%ethanol,add2mlofsodiumborateTSand1mlofa1in10,000solutionof2,6-dichloroquinonechlorimideinabsoluteethanol,

4、andmix.Abluecolourappears.PURITYSulfatedash(Vol.4)Notmorethan0.05%Test5gofthesample(MethodI)Lead(Vol.4)Notmorethan2mg/kgDetermineusinganatomicabsorptiontechniqueappropriatetothespecifiedlevel.Theselectionofsamplesizeandmethodofsamplepreparationmaybebasedontheprinciplesofthemethoddescrib

5、edinVolume4,“InstrumentalMethods.”PhenolicimpuritiesNotmorethan0.5%SeedescriptionunderTESTSTESTSPURITYTESTSPhenolicimpuritiesDeterminebyThin-LayerChromatography,(seeVolume4)usingsilicagelGplates.Solution1:Dissolve0.25gofthesamplein10mlofether.Solution2:Dilute1mlofSolution1to10mlwithethe

6、r,andthendilute1mloftheresultingsolutionto20mlwithether.Usethefinaldilutionassolution2.ProcedureSpot2µleachofSolution1andofSolution2onseparateTLCplates.Placeeachplateinadevelopingchambercontainingchloroformassolvent,andallowthesolventfronttoascendtoapoint15cmabovethesamplespots.Developt

7、hechromatogramsbysprayingwithanaqueousmixtureofequalvolumesof2%ferricchloridesolutionand1%potassiumferricyanidesolutionmixedpriortouse.Thebluecoloursproducedmaybeintensifiedbysprayingwith2Nhydrochloricacid.Anybluespotsappearing(otherthanthemajorspotandthespotatRf0.35)arenotmore