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1、CALCIUM5'-RIBONUCLEOTIDESPreparedatthe18thJECFA(1974),publishedinNMRS54B(1975)andinthFNP52(1992).Metalsandarsenicspecificationsrevisedatthe57JECFAth(2001).AnADI‘notspecified’wasestablishedatthe18JECFA(1974).SYNONYMSCalciumribonucleotides,INSNo.634DEFINITIONChemicalnames(Mixt
2、ureof)calciuminosine-5'-monophosphateandcalciumguanosine-5'-monophosphateChemicalformulaC10H11CaN4O8P·xH2OandC10H12CaN5O8P·xH2OStructuralformulaCalcium5’-guanylateCalcium5’-inosinateAssayNotlessthan97%andnotmorethantheequivalentof102%ofC10H11CaN4O8PandC10H12CaN5O8P,calculate
3、dontheanhydrousbasis.TheproportionofC10H11CaN4O8PorC10H12CaN5O8Ptothesumofthemisbetween47%and53%.DESCRIPTIONOdourless,whiteoroff-whitecrystalsorpowderFUNCTIONALUSESFlavourenhancerCHARACTERISTICSIDENTIFICATIONSolubility(Vol.4)SparinglysolubleinwaterTestforribose(Vol.4)Passest
4、estTestfororganicphosphatePassestest(Vol.4)Test5mlofa1in2,000solutionTestforinosinicacidTo2mlofa1in2,000solutionadd2mlof10%hydrochloricacidand0.1gofzincpowder,heatinawaterbathfor10min,andfilter.Coolthefiltrateinicewater,add1mlofa3in1,000sodiumnitritesolution,shakewell,andall
5、owtostandfor10min.Add1mlofa1in200ammoniumsulfamatesolution,shakewell,andallowtostandfor5min.Add1mlofa1in500N-(1-naphthyl)-ethylenediaminedihydrochloridesolution.Avioletredcolourisproduced.TestforguanylicacidTo1mlofa1in5,000solutionadd1mlof10%hydrochloricacid,heatinawaterbath
6、for10min,cool,andadd0.5mlofFolin-CiocalteuTSand2mlofsaturatedsodiumcarbonatesolution.Abluecolourisproduced.Testforcalcium(Vol.4)PassestestPURITYWater(Vol.4)Notmorethan23%(KarlFischerMethod)pH(Vol.4)7.0-8.0(1in2,000soln)WatersolublematterTo1gofthesample,add50mlofwater,allowto
7、standfor10minwithoccasionalshaking,filterthroughanalyticalgradefilterpaper(WhatmanNo.42orequivalent).Evaporatea25mlportionofthesolutiontodrynessonawaterbathanddrytheresidueat1057for1h.Residueweighslessthan80mg.AminoacidsNotdetectablebythefollowingtest:To5mlofa1in2,000solutio
8、nadd1mlofninhydrinTSandheatfor3min.Nocolourisproduced.RelatedforeignChromat
