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1、AgilentLC-MS/MS在环境中的解决方案Dr.LaiCongfang（赖丛芳博士）液质联用产品工程师LifeScience&ChemicalAnalysis2013-03Page1我们失窃的未来byColborn,Dumanoski,andMyers-Reducedimmunity-Diminishedfertility-Decreasedintelligence……Page2环境分析分类－按基质分类气体分析水分析土壤和淤泥分析•Pre-salesenvironmental•Ozoneprecursors•Drinkingwatertesting•Smokestacke
2、missions•Sourcewater(lakes,•Contaminatedsite•Pointsources–landfills,rivers,groundwateranalysis–what’sinthechemicalplants,etcusedfordrinkingwater)soil?•Workplaceair•Wastewater:•Contaminatedsite(EnvironmentalHealth1.Publicsewagemonitoring–isthesiteandSafety)treatmentplantscleanyet?•Indoorairan
3、alysis(Sick2.Industrial•LeakingundergroundBuildingSyndrome)dischargesstoragetankanalysis•SludgeanalysisPesticidesPage3环境分析－按化合物性质分类•挥发性物质分析(Volatilesanalysis)－Drinkingwater,wastewater,soil,sludge－Headspace/GC/MS－Purge-and-Trap/GC/MS•半挥发性物质分析(Semivolatilesanalysis)－Drinkingwater,wastewater,so
4、il,sludge－Solventextraction–thenGCorGC/MS•极性，热不稳定，低挥发性或非挥发有机物(Polar,labile,and/orverylowvolatilityorganics)LC或LCMS•无机分析(Inorganicanalysis)－Water,soil,sludge－ICP/MS(competeswithAA,ICP/OES)PesticidesPage4Enviro.Workflow:Screen,ConfirmandQuantifySCQRepresentativeGC/MS(PTV)SIM/ScanSample–forknow
5、n/unknown401DeconvolutionFinalReportS83C256QLibrarySearch(+backflush)LC/QQQMRM–forknowntargetsSSampleExtractionCQExactMassAnotherinjectionforLC/QTOForTOFFullSpectrumDatabaseSearchMS/MS(QQQorQTOF)–forunknowncompoundsMSMassHunterExtractMFEClean-upMSSQFragmentationCMolecularFormulaGenerationMS/
6、MSC16H19N3PClC15H25OPSClC18H21OPClPage5AgilentLC-MS/MS在环境中的解决方案PPCPs：药品和个人护理用品环境中的多农药残留分析On-lineSPE全自动饮用水里中性除草剂分析PFOA/PFOS(全氟辛酸、全氟辛烷磺酸及盐类)多酚类和羟基取代溴代苯醚分析Page6TargetScreeningofPPCPsinWaterMatricesUsingUHPLCandLC/MS/MSQQQPharmaceuticalsandPersonalCareProducts(PPCPs)refer,ingeneral,toanyproductu
7、sedbyindividualsforpersonalhealthorcosmeticreasonsorusedbyagribusinesstoenhancegrowthorhealthoflivestock.PPCPscompriseadiversecollectionofthousandsofchemicalsubstances,includingprescriptionandover-the-countertherapeuticdrugs,veterinarydrugs,fragran
