Cd(Ⅱ)配合物的合成、结构和DNA结合性质.pdf

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1、第32卷第3期无机化学学报V0l_32No．32016年3月CHINESEJ0URNALOFINORGANICCHEMISTRY555—560喹啉缩氨基硫脲Co(HI)／Cd(ID配合物的合成、结构和DNA结合性质毛盼东1闰玲玲，王文静2杨倩倩2崔猛强1王元，吴伟娜1河南理工大学物理化学学院．焦作454000)(河南理工大学材料科学与工程学院，焦作454000)摘要：合成并通过单晶衍射、元素分析、红外光谱表征了配合物【CoC1·2CH，OH(1)和【cd(2)的结构(HL为喹啉一8一甲醛缩硫代氨基脲)。单晶衍射结果表明，配合物1和2中金属离子采取相同的配位模式，分别

2、与来自硫醇化脱质子的配体的4个N原子和2个S原子配位．采取扭曲的八面体配位构型。配合物1和2能够与DNA结合，结合模式分别为静电结合和部分插入。关键词：喹啉；缩氨基硫脲；配合物；晶体结构；DNA结合性质中图分类号：O614．81+2；O614．24+2文献标识码：A文章编号：1001-4861(2016)03-0555—06DoI：10．11862／CJIC．2016．064Syntheses，CrystalStructuresandDNA-BindingPropertiesofCoOID／Cd(II)ComplexeswithQuinolineThiosemica

3、rbazoneLigandMAOPan—DongYANLing—Ling，WANGWen-JingYANGQian·QianCUIMeng—QiangWANGYuan，WUWei-NafDepartmentofPhysicsandChemistry,HenanP0echnicUniversity,$aozuo，Henan454000,China)(2SchoolofM~endsScienceandEngineering,HenanPolytechnicUniversity,Jiaozuo，Henan454000,China)Abstract：Twocomplexes

4、[CoC1·2CH3OH(1)and[CdL=](2)(HL=(quinolin一8一ylmethylene)thiosemicarbazide)havebeensynthesizedandstructurallydeterminedbysingle-crystalX-raydiffraction．TheresultsshowthatthemetalionineachcomplexwithadistortedoctahedrongeometryissurroundedbytwoanionicthiosemicarbazoneligandwithN2Sdonorset

5、．Complexes1and2canbindtoDNAviaelectrostaticintercalationandpartialintercalationmodes。respectively．CCDC：1436092，1；1436093，2．Keywords：quinoline；thiosemicarbazone；complex；crysta1structure；DNA—bidingpropertyThiosemicarbazonesfTSCs)andtheirmetalcom—DNAbindingandinhibitionofproteinsynthesis[

6、I-10]．plexes，especiallythetransitionmetal，haveattractedUptonow，alargeamountofTSCsmetalscontainingintensityattentioninthecoordinationchemistrysix．memberheterocycleshavebeenf0undtopossessbecauseoftheirhi【ghbiologicalandpharmaceuticalconsiderableantitumoractivity埘．However，theactivities，su

7、chasantibacterial，antiviral，antifungal，studiesonthecomplexeswithTSCsbearingcond-andantitumoractivity[”．Infact．themechanismofensedheterocyclesarerelativelyfew[3,11-13]．Recently。antitumoractioniSstillcontroversialinmanyrespectsseveralCu(II)complexeswithquinolin一8-ylmethylene)andhasbeen