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《Global burden of dementia in the year 2000summary of methods and data sources.2000年度的全球痴呆症负担： 方法和数据来源综述.pdf》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、Globalburdenofdementiaintheyear2000:summaryofmethodsanddatasources.ColinMathers1,MatildeLeonardi21.IntroductionthDementiawasestimatedtobethe10leadingcauseofnon-fatalburdenintheworldin1990,accountingfor2.6%oftotalYLD,aroundthesamepercentageascongenitalmalformations(1)IntheVersion
2、2estimatesfortheGlobalBurdenofDisease2000study,publishedintheWorldHealththReport2002(2),dementiaisthe11leadingcauseofYLDsatgloballevel,accountingfor2.0%oftotalglobalYLDs.Dementiaisdifficulttodefineanddetectinthepopulation.Evenwiththedifficultiesofdeterminingprevalenceandincidenc
3、e,itisclearthatdementiacausesasubstantialburdenglobally.ThisdraftpapersummarisesthedataandmethodsusedtoproducetheVersion2estimatesofdementiaburdenfortheyear2000.2.CaseandsequelaedefinitionsDementiaisasyndromecausedbyarangeofillnesses.Mostarecurrentlyincurable,andcauseprogressive
4、,irreversiblebraindamage.TheyincludeAlzheimer'sdisease(themostcommoncause),vasculardisease,frontallobedementiaandLewyBodydisease.Symptomsofdementiacanincludememoryloss,difficultieswithlanguage,judgement,andinsight,failuretorecognisepeople,disorientation,moodchanges,hallucination
5、s,delusions,andthegraduallossofabilitytoperformalltasksofdailyliving.Alldementiasareincludedinthecasedefinition(Table2.1),whichremainsunchangedfromtheGBD1990study(3).Table2.1:CaseandsequelaedefinitionsfordementiaCausecategoryGBD2000CodeICD9codesICD10codesDementiaU087290,330,331F
6、01,F03,G30-G31SequelaDefinitionCasesMild,moderateandsevereAlzheimerdisease,senileandotherdementias.1EpidemiologyandBurdenofDisease,WHOGeneva2HealthFinancingandServices,WHOGenevaGlobalBurdenofDisease200023.IncidenceandprevalenceofdementiaDementiaisanextremelycommonconditionamongt
7、heelderly.Over100epidemiologicalsurveyshavenowbeenpublishedfrommanycountries(4).Methodologicaldifferencesmakecomparisonsdifficult,althoughseveralmeta-studiesdescribedbelowprovidebaselinematerialfordevelopedcountries.Anintegrativeanalysisof47surveysacross17countrieshassuggestedap
8、proximateratesunder1%fordementiafromanycauseinp
