as and inflammation

《as and inflammation》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、动脉粥样硬化研究现状及挑战Coronaryheartdisease(CHD)根据WHO2011年统计，全世界每年约有1710万人死于心血管疾病，占全部死亡人数的29%http://www.who.int《中国卫生统计年鉴2008》冠心病占所有心脏病死亡64%占国民收入4%3098亿人民币FromhealthyarterytoheartattackInflammationinatherosclerosis.Nature2002LumenLipidCoreFibrouscapShoulderIntimaMediaElas

2、ticlaminæInternalExternal动脉粥样硬化（atherosclerosis,AS）VulnerableplaqueEndotheliumLipid-RichCoreThickFibrousCapThinFibrousCapMacrophageLumenFalkE,etal.Circulation.1995;92:657-671.PlateletsStableUnstableThrombus动脉粥样硬化（atherosclerosis,AS）InflammationinASM1,M2macroph

3、ageInflammationresolutionEfferocytosisInflammasomeNecroptosisEndoplasmicreticulumstressAS机理研究历程1862年脂质浸润学说：血脂侵入动脉壁并在局部沉积，刺激SMC增生、促进泡沫细胞形成；脂质及其降解物和泡沫细胞刺激纤维增生，形成斑块病灶20世纪60年代后期平滑肌细胞克隆学说：中膜SMC发生突变获得增生优势，形成一个单克隆VSMC突变VSMCVSMCVSMCVSMCVSMCVSMCVSMCAS机理研究历程1973年损伤反应学说：V

4、EC损伤危险因素血小板粘附聚集VSMC增殖VSMC和单核细胞迁移AS机理研究历程1993年炎症免疫学说：VEC损伤致炎因子局部炎症反应AS机理研究历程Immunecomponentsoftheatheroscleroticplaque.InnateimmunityinASMacrophageinASAdaptiveimmunityinASTlymphocyteinASM1andM2macrophagesClassicallyactivatedAlternativelyactivatedPro-inflammation

5、Anti-inflammationInflammationresolutionbyM2DefectiveinflammationresolutioninvulnerableplaqueClearanceofapoptoticcellsbyprofessionalphagocytes(efferocytosis)Defectiveefferocytosisinhibitsinflammationresolution“find-me”signalsLPC,S1P,CX3CL1,ATP/UTPInflammasomeAde

6、cadeago,JurgTschoppintroducedtheconceptoftheinflammasomeInitiatetheinflammatoryresponsecontributedtoarenaissanceinthefieldsofinnateimmunityandcelldeathInflammasomeactivityregulateshomeostaticprocessesandinflammationTNFareceptor-mediatedactivationofapoptosisandne

7、croptosisNecroptosisisinducedbyvariousstimuliAdaptivethermogenesisMacrophageERstressininflammationandapoptosisERstress–inducedapoptosisinAS