cells of inflammation and immunity：炎症和免疫细胞

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1、CellsofinflammationandImmunityG.Wharfe2005ImmunesystemDetectandrespondtoantigensProtectsagainstpathogenicmicroorganismsAlsoelicitsresponseagainstnoninfectiousforeignorganismsUsedininflammatoryresponseandtissuerepairImmuneresponseResponseneedstobequickandefficientTwosystemsInnateAdaptiveCellso

2、fIRAllderivedfromBMstemcellsInfluencedbygrowthfactorsBeginasmultipotentstemcellDevelopintocommittedstemcellsInnateimmunesystemFirsttorespondLimitsinfectionbeforeadaptiveresponseUsuallyinvolvenonlymphoidcellsCellsaremacrophagesandpolymorphonuclearneutrophils(PMN)Alsoinvolvescomplementandacutep

3、haseproteinsIfinnateimmunitycuresinfection-noadaptiveimmunitydevelopsNormalhaematopoiesisAdaptiveimmunityInducibleantigenspecificresponsePrimarylymphoidorgansproducelymphocytescapableofrespondingtovariousantigensLymphocytesformnaïvepoolinbloodLymphocytescirculateinperipherallymphoidorgansLoca

4、tionforAg-dependentIRImmunoglobulinCellsofinnateimmunesystemAllarebonemarrowderivedLineagecommitmentdependsonstromalcontactandcytokinesDendriticcells-AntigenpresentingcellsDevelopfromperipheralbloodmonocyteprecursorsFoundintheinterstitiumandTcellareasStimulateAgspecificTcellsPhagocyticcellsPM

5、N’sMacrophagesGranulocytesInflammatorycellsContaincytoplasmicgranulesNeutrophilsEosinophilsBasophilsNeutrophilStagesofgranulocytematurationNeutrophilsMajorphagocyticgranulocyteContainmultilobednucleusNeutrophilicgranulesRespondtochemotacticstimuliActivatedbymacrophageandendothelialderivedcyto

6、kinesMajorcellofacuteinflammationPrimaryeffectorcellsinIRtopyogensNeutrophilsHaveFcreceptorsforIgGandc’BindandphagocytoseopsonisedantigensLinkbetween2armsofimmunesystemRegulatesactivationandrecruitmentofmacrophagesbycytokinesPhagocytosisPrincipalmechanismofpathogensEntersiteofinfectionOpsonin

7、sproducedtoallowphagocytosisTakenintovacuoleKillingbyaerobicoranaerobicmechanismsCytokineinductionPhagocytosisEosinophilEosinophilsContaineosinophilicgranulesExpressFcreceptorsforIgEIgEprevalentinparasiticinfectionsIgEmediatesactivationofeosi