冠状病毒Coronavirusl论文-2009 Severe acute respiratory syndrome-coronavirus and human coronavirus-NL63_ an updated overview.pdf

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1、Severeacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63:anupdatedoverviewaa,bVanessaDittandOliverSchildgenSevereacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63,thoughbothbelongingtodifferentgroupsofthesamegenus,areinterestingrepresentativesoftheirkind;

2、thefirstoneisofzoonoticorigin,accountedforthepandemicin2002/2003thatwasdistributedworldwideandhadamortalityrateofabout10%,theotheronewasidentifiedlaterandprobablyhasbeencirculatingwithinthepopulationforcenturiesandbelongstothosevirusesthatcausethe‘commoncold’.Alotofefforthasbee

3、nmadetoinvestigatebothvirusesandtounderstandtheirdifferencesandtheirsimilaritieswithregardtofurtherzoonoticevents.Thisreviewgivesanoverviewofsevereacuterespiratorysyndrome-coronavirusandhumancoronavirus-NL63,theirhistoryandthecurrentstateofresearch.ß2009WoltersKluwerHealth

4、Li

5、ppincottWilliams&WilkinsReviewsinMedicalMicrobiology2009,20:19–28Keywords:coronaviruses,NL63,severeacuterespiratorysyndromeIntroductionandsimilaritiesandtheircharacteristics.ThisreviewwillmainlyfocusonSARS-CoVandHCoV-NL63.Sincethefirsthumanpathogeniccoronaviruses(HCoV)-229Eand

6、HCoV-OC43wereidentifiedinthe1960sandassociatedwithmildrespiratorydiseases[1,2],onlylittlenewinformationhademergedinthisfielduntilthebeginningofthiscentury.SuddenlythefocuswasIdentificationofsevereacuterespiratorydirectedtowardscoronavirusesagainasaspecial,mean-syndrome-coronavir

7、usandhumanwhilewellknownmemberofthisgroupappearedincoronavirus-NL632002/2003[3–5]intheprovinceofGuangDong(China)andcaused‘severeacuterespiratorysyndrome(SARS)’;Severaltechniqueswereemployedtocharacterizeandfatalsymptomsthatwereveryunusualforcoronavirusesidentifythecausativeag

8、entofSARS.Patientmaterialwasastheywereconsideredtobenonhazardousatthistime.inoculatedontorhesusmonkeykidneycells(fRhk4)toStrenuouseffortsweremadetoidentifyandcharacterizeobserveforcytopathiceffects;testsforotherknownthisnewpandemicthreatandtocurbit.respiratoryviruseswerenegat

9、ive.Electronmicroscopyrevealedthemorphologyandledtocharacterizationo