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1、20863r.qxd10/21/200511:23AMPage1057AntibodytitersagainstbovinecoronavirusandsheddingofthevirusviatherespiratorytractinfeedlotcattleSarahL.Lathrop,DVM,PhD;ThomasE.Wittum,PhD;StevenC.Loerch,PhD;LouisJ.Perino,DVM,PhD;LindaJ.Saif,PhDandphysicalstressesov
2、erwhelmthedefensemechanismsObjective—Todescribepatternsofseroconversiontoofananimal’srespiratorytract,allowingcommensalbacte-bovinecoronavirus(BCV)andsheddingofBCVfromtherespiratorytractinfeedlotcattle.riaofthenasalcavity,includingMannheimiahaemolyti
3、ca(formerlyknownasPasteurellahaemolytica)andPmulto-Animals—1,074calvesinfeedlotsinOhio,Texas,and1-4cida,toinfectthelungs.NumerousviruseshavebeenNebraska.implicatedinBRDC,includingbovinerespiratorysyncy-Procedure—Nasalswabspecimenswereobtainedattialvi
4、rus,bovineherpesvirus-1,parainfluenza-3virus,andtimeofarrival(day0)andatvarioustimesduringthe1-4bovineviraldiarrheavirus.Mostcattlearrivingatfeed-initial28daysafterarrivalatfeedlots.Specimenslotsarevaccinatedagainsttheseviruses.5weretestedforBCV,usin
5、ganantigen-captureELISA.SerumsampleswereobtainedattimeofarrivalandRecently,investigatorsisolatedbovinecoronavirus(BCV)fromcattleinfeedlots.6-8Cattlesheddingthisagain28daysafterarrival;serawereanalyzedforanti-bodiestoBCV,usinganantibody-detectionELISA
6、.virusatthetimeofarrivalareatincreasedriskfordevel-opingrespiratorytractdisease7;however,itisunknownResults—Samplesfrom12groupsofcattleentering7feedlotsduringa3-yearperiodrevealedthat78ofwhetherthisisanincidentalfinding,becausethevirus81,074(7.3%)cat
7、tleweresheddingBCV(range,0toalsocanbeisolatedfromhealthycattle.Furthermore,it35.9%withinspecificgroups).Attimeofarrival,508isnotcertainthatBCVisacontributortoBRDC.Givenof814(62.4%)cattlehadlow(<50)orundetectabletheacknowledgedrolesofothervirusesinBRD
8、C,itisBCVantibodytiters.SeroconversiontoBCVduringpossiblethatBCValsomayactsynergisticallywithothertheinitial28daysafterarrivalwasdetectedin473ofinfectiousagentsandstressorstocontributetopneumo-814(58%)cattletested(range,20.3to84.1%withinniaincattlein
