冠状病毒Coronavirusl论文-1994 Cervical lymphoid tissue but not the central nervous system supports proliferation of virus-specific T lymphocytes.pdf

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1、JournalofNeuroimmunologyELSEVIERJournalofNeuroimmunology53(1994)73-81Cervicallymphoidtissuebutnotthecentralnervoussystemsupportsproliferationofvirus-specificTlymphocytesduringcoronavirus-inducedencephalitisinratsH.Imricha,,,S.Schwenderb,A.Heina,R.D6rriesaaInstitutfi~rVirologieundImmunbiologieder

2、UniversitiitWiirzburg,Versbacherstr.7,D-97078W'tirzburg,GermanybZentrallaborderMedizinischenKlinikderUniversitiitWiirzburg,Wiirzburg,GermanyReceived22February1994;revisionreceived26April1994;accepted27April1994AbstractTheCD4÷Tlymphocyteresponseinthecentralnervoussystem(CNS)andcervicallymphnodes(

3、CLNs)ofratswithdifferentsusceptibilitytocoronavirus-inducedencephalitiswasinvestigated.ThemajorityofCD4+Tlymphocytesenteringthevirus-infectedCNSinthecourseoftheinfectionareprimedcellsthatneitherproliferateexvivonorcanbestimulatedtoproliferationbyviralantigensormitogeninvitro.Incontrast,Tlymphocy

4、testakenfromCLNsofthesameanimalsrevealedastrongproliferativeresponse.RestimulationofCLNlymphocytesbyviralantigensdisclosedastrikingdifferencebetweenthedisease-resistantratstrainBrownNorway(BN)andthesusceptibleLewis(LEW)strain.WhereasBNlymphocytesrespondedasearlyas5dayspostinfection,ittookmoretha

5、n11daysuntilacomparableproliferationwasdetectableinLEWlymphocytes.FromthesedatawepostulatethatthemajorityofTlymphocytesenteringthevirus-infectedbrainaftersensitisationandexpansionincervicallymphnodesisunresponsivetofurtherproliferationsignalsandthatthekineticsandmagnitudeofTlymphocytestimulation

6、inCLNsplayanimportantroleintheclinicalcourseoftheinfection.Keywords:Viralencephalitis;Tcells;Proliferation;Centralnervoussystem;CervicallymphnodesI.Introductionantigensintheinflamedvirus-infectedCNS(SedgwickandD6rries,1991;Sedgwicketal.,1991)raisesmanyTheunaffectedcentralnervoussystem(CNS)isanqu

7、estionswithrespecttoinfiltratingCD4÷Tlympho-immunologicallysequesteredorgan.Thisisevidencedcytes.IthasbeenshowninvitrothatexpressionofbylowexpressionofMHCantigensonveryfewMHCclassIIantigenscanbeinducedbyy-interferonmeningeal