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1、Viruses,immunityandmentaldiseases307cerebralhemispheres,includingtheolfactorybulbs,septalnuclei,cingulategyrus,hippo-campusandhypothalamus.Infectionof4-week-oldratsresultedinapersistentinfectionintheCNS.Animalsdevelopedatransientimmunologicallyspecificencephal
2、iticresponsewhichcausedbizarre,hyperactiveandaggressivebehavior.Ratsrecoveredfromtheence-phalitiswithhydrocephalicpathologicaldeficitsresultingfromlysisofsomeinfectedneurons.Behaviorhencewascharacterizedbyinactivityandpassiveness.Infectioninthebrainpersisted.I
3、mmunosuppressionofthemiceresultedinverysimilarvirus-cellinter-actionbutnoencephalitisoccurredandanimalsdidnotbecomeill.Thebehavioraldiseasewasthereforeduetoresponsesofinfectedneuronstriggeredbyspecificallysensitizedin-flammatorycells.Abstract33.Transmissionstu
4、diesofneurologicalandpsychiatricdiseaseinthemarmosetR.M.Ridley,H.F.Baker,T.J.Crow,A.J.Cross,G.W.Roberts,G.R.TaylorDivisionofPsychiatry,ClinicalResearchCentre,Harrow,U.K.andL.W.DuchenInstituteofNeurology,QueenSquare,London,U.K.Thebehaviourof6marmosets(Callithri
5、xjacchus)inoculatedintracerebrallywithCSFfromschizophrenicpatientswascomparedovera23yearperiodwiththebehaviourofmarmosetsinoculatedwithCSFfrompatientswithneurodegenerativediseaseorfrompatientsunder-goingspinalanaesthesiawhosufferedfromnoneurologicalorpsychiatr
6、icdisorders.Ani-malsinoculatedwithCSFfrompsychiatricorneurologicalpatientsbecameprogressivelyandsignificantlylessactivethananimalsinoculatedwithCSFfromotherpatientsalthough,post-mortem,noconsistentdifferencesbetweengroupsofanimalswerefoundinlight-orelectron-mi
7、croscopicbrainexamination,brainbiochemicalanalysisorviralisolation.Inanotherexperimentall4marmosetsinoculatedintracerebrallywithbrainmaterialfromapatientwiththeGerstmann-Str~usslersyndrome(G.S.S.)developedaspongiformencephato-pathywhichwasindistinguishablefrom
8、thatshownbyanother4marmosetsinoculatedwithbrainmaterialfromatypicalcaseofCreutzfeldt-Jakobdiseaseinacomparabletimecourseof20-32months.ThefamilialoccurrenceofaviraldiseaseinG.S.S.wi
