聚羟基丁酸己酸酯_聚碳酸亚丙酯共混材料作为血管组织工.pdf

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1、万方数据基础医学中国组织工程研究与临床康复舅11卷第巧期2007—09—02出版JournalofClinicalRehabilitativeTissueEngineeringResearchSeptember2,2007V01．11，No35聚羟基丁酸己酸酯／聚碳酸亚丙酯共混材料作为血管组织工程支架的性能特征☆张玲1，敖强2，贺庆1，王干1，奚静1，公衍道1，张秀芳11StateKeyLaboratoryofBiomembrane-MembraneBioengineering，DepartmentofBio[ogicalSciencesandBiotec

2、hnology，TsinghuaUniversity，Beijing100084，China；2InstituteofCerebraINeweDisease，ResearchAcademyofLifeSciences，TsinghuaUniversity，Beijing100049．ChinaZhangLing☆Studyingdoctorate．LaboratoryforStareKeyBiomembrane．MembraneBIoenglneerIng，DepartmentofBiologicalSciencesandBiotechnology，Tsi

3、nghuaUniversity．Beijing100084，Chinazlin903@mailstsinghuaeducnCOrresDOndencetO：ZhangXiu-fang，Professor，StateKeyLaboratoryofBiomembrane-MembraneBIOengIneerfng，DepartmentofBiologicalSciencesandBiotechnoiogy，TsinghuaUniversity，Beijing100084。ChinaPropertiesofpoly(3-hydroxybutyrate·co·3

4、-hydroxyhexanoate)／polypropylenecarbonateblendedmaterialsasascaffoldforbloodvesseltissueengineeringAbstractAIM：ToimprovethemechanicaIpropertyofpoly(3-hydroxybutyrate—co-3一hydroxyhexanoate)(PHBHHx)andprocessingabilityofpolypropylenecarbonate(PPC)，thePHBHHxandPPCwereblendedinsolvent

5、andmadeintofilmsandtubularscaffolds．Theadhesionofrabbilaortasmoothmusclecell(RaSMC)onthef¨msandthemechanicaIpropertyofIubularscaffoldswereevaluatedtoselectapropermaterialasscaffoldforbloodvesseItissueengineeringMETHoDS：TheexperimentwasconductedjntheStateKeyLaboratoryofBiomembranea

6、ndMembraneBioengineering，DepartmentofBiologicaISciencesandBiOtechn0IOgy，TsinghuaUniversityfrOmAugust2006toApril2007．(DRaSMCswereincubatedonthef¨msfromdifferenlweightratiosofPHBHHx／PPCblendedsolution(PHBHHx：PPC=0：10，3：7，5：5，7：3，and10：0)for24hoursandtheamountsofadhesionondifferentf¨

7、msweredetectedbvCCK-8kit．②Tubularscaffoldswerepreparedusingthermally—inducedphaseseparation(TIPS)andfreeze．dryingmethods．andthentheyweredippedintotheirsolutionsrespectivelyanddriedinairAdriedmembranewasformedonthesurfaceofscaffolds．Themorphologyofthescaffoldswasobservedbyscanninge

8、lectronmicroscopy(SEM)：theporosit