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1、DesignandAnalysisofBiomolecularCircuitsHeinzKoepplDouglasDensmoreGianlucaSettiMariodiBernardoEditorsDesignandAnalysisofBiomolecularCircuitsEngineeringApproachestoSystemsandSyntheticBiologyABCEditorsHeinzKoepplDouglasDensmoreETHZurichDepartmentofElectricalAutomaticControlL
2、aboratoryandComputerEngineeringPhysikstrasse3BostonUniversity8092Zurich8SaintMarysSt,BostonMassachusettsSwitzerlandUSAkoeppl@ethz.chdougd@bu.eduGianlucaSettiMariodiBernardoUniversit`adiBolognaUniversit`adiNapoliFedericoIIARCESViaClaudio21ViaToffano2/280125Napoli40125Bologna
3、ItalyItalymario.dibernardo@unina.itgianluca.setti@unife.itISBN978-1-4419-6765-7e-ISBN978-1-4419-6766-4DOI10.1007/978-1-4419-6766-4SpringerNewYorkDordrechtHeidelbergLondonLibraryofCongressControlNumber:2011926002cSpringerScience+BusinessMedia,LLC2011Allrightsreserved.Thiswo
4、rkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(SpringerScience+BusinessMedia,LLC,233SpringStreet,NewYork,NY10013,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretr
5、ieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionastowhether
6、ornottheyaresubjecttoproprietaryrights.Printedonacid-freepaperSpringerispartofSpringerScience+BusinessMedia(www.springer.com)PrefaceThebookisdevotedtothedesignandanalysisofbiomolecularcircuitsasconsideredinsystemsbiologyandsyntheticbiologytwoverydynamicandpromisingfieldsofre
7、search.Combiningexpertiseandknow-howfromthebiolog-icalandphysicalscienceswithcomputerscience,mathematicsandengineering,theirpotentialtoimpactsocietyisonlylimitedbytheimaginationofthoseworkinginthefields.Syntheticbiologypromisestointroducenewbio-therapeutic,bio-remediation,an
8、dbio-sensingapplications.Forexample,synthesizingbacteriatoseekoutandde-stroycancer