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ID:50987629
大小:4.56 MB
页数:51页
时间:2020-03-17
《防治高同型半胱氨酸血症的新思路.ppt》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、ANEWSTRATEGY---TOTREAT/PREVENTEHYPERHOMOCYSTEINEMIAHomocysteine(HCY)isasulfur-containingaminoacidproducedduringcatabolismoftheessentialaminoacidmethionine.HomocysteinemetabolismHYPERHOMOCYSTEINEMIANormalhumanplasmaHCYconcentration5-15μmol/LHyperhomocysteinem
2、ia16-30μmol/L30-100μmol/L>100μmol/LHyperhomocysteinemiaanindependentcardiovascularriskfactorMechanismofCellinjurybyHCYOxidativestressInflammationpathwayEndoplasmicreticulumstressVSMCsover—proliferationInterferelipidmetabolismInterfereendotheliacoagulationact
3、ivitiesInterfereL-arg-NOS/NOpathwayClinicaltherapyandcurrentquestionsVitaminB6,B12andfolicacid—themaintreatmentstrategyIndicationneuraldegenerationEndotheliaprotectionperseBetaineN-athelcysteine,NAC;VitEPeptides----CNP,ADM,CGRPetc.HormoneDrugsTherapeuticNews
4、trategytohyperhomocysteinemiaSulfur-containingaminoacidmetabolismsystem----superregulationfamilyGenerationfromthemethionineIndependentbiologicaleffectsInteractiveregulationandantagonismEndogenousantagonistasanewtherapy/preventionforhyperhomocysteinemia???Tau
5、rineRegulateosmoticpressureStabilizecellmembraneRegulationfreeCa2+InhibitlipidperoxidationRegulateendotheliacontraction/relaxationfactorsynthesize/releaseASanendogenousprotectantinvariousdiseasesincludingcardiovasculardiseasesAntagonismtocardiovascularinjury
6、byHCYEndotheliaInjurystructuredisorderETreleaseLDHreleaseProliferationVSMCsproliferationMyocardiumHCYloweredtautrineconcentrationInhibittaurineuptakeIncreasetaurinereleaseMitochondriaInjuryMethininefoodinducedhyperhomocysteinemiaMyocardialMitochondria(×40000
7、)ControlTaualoneMetaloneMet+TauTaurineantagonismtoHCYcardiovascularinjurybyoxidativestressMitochondriamembraneLipidperoxidationMDAConjugateddieneMyocardialMitochondriaO2-productionandMn-SODactivityMn-SODMyocardialMitochondriaH2O2productionandCATactivityCAT**
8、p<0.01vscontrol;#p<0.05,##p<0.01vsMetMyocyteH2O2productionabMyocyteMitochondriaH2O2productioninvitroMitochondriaO2-productioninvitroSub-mitochondriaH2O2andO2-Mitochondriaenzyme-complex-IIandIIIr
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