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1、Alzheimer’sDisease阿尔茨海默症RonaldWilsonReagan罗纳德·威尔逊·里根第40任（第49-50届）美国总统president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”briefintroduction01Pathogeny＆Treatment03Clinicalmanifestatio
2、n02Other04Catalogbriefintroduction1What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.临床症状Clinicalsymptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executivedysfunction痴呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.TwotypesAlzheimer's
3、disease(AD)<65yearsoldseniledementia(SDAT)≥65yearsoldNameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.Scientistsalsohavefoundotherbrainchangesinpeople
4、withAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.Clinicalmanifestation2ClinicalmanifestationⅠ期Ⅱ期Ⅲ期death1-3years2-10years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20yearsDegradationo
5、fmemoryandcognitionWilliamUtermohlen的自画像DegradationofmemoryandcognitionWilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughsel
6、fportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).Degradationofmemoryandcognit
7、ion"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfun
8、ctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.Pathogeny＆Treatment3Path
