[精品]探讨动态动脉硬化指数和尿微量白蛋白与冠状动脉狭窄程度的相关性.doc

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1、探讨动态动脉硬化指数和尿微量白蛋白与冠状动脉狭窄程度的相关性探讨动态动脉硬化指数和尿微量白蛋白与冠状动脉狭窄程度的相关性摘要：冃的：探讨动态动脉硬化指数(AASI)和尿微量白蛋白(MAU)与冠状动脉狭窄程度的相关性。方法：100例冠心病患者根据冠状动脉造影检查结果分为单支病变组(33例)、双支病变组(35例)、多支病变组(32例),同时设立正常对照组(30例)。测定和比较各组的AASI.MAU；以Gensini积分表示冠状动脉狭窄程度，评价Gensini积分与AASKMAU的相关性。结果：多支病变组的AASKMAU分别为0.7±0.1,(93.4±2

2、1.3)mg/L,双支病变组的AASKMAU分别是0.6±0.2,(70.7±20.2)mg/L,单支病变组的AASKMAU分别是0.4±0.1,(36.5±13.4)mg/L,均显著高于正常对照组(P〈0・05),各病变组之间两两比较，差异具有显著性(卩〈0・05)。Gensini积分与AASI存在显著正相关("0.674,P<0.01),与MAU存在显著正相关(—0.732,P<0.01)o结论：AASI和MAU水平随冠脉病变支数的增加而上升，AASI和MAU水平与冠状动脉狭窄程度具有显著的正相关。关键词：动态动脉硬化指数(AASI)；尿微量白蛋

3、白(MAU)；冠状动脉狭窄；相关性ABSTRACT：OBJECTIVE：ToevaluatetherelationshipbetweenAmbulatoryArterialStiffnessIndex(AASI),microalbuminuria(MAU)andtheextentofcoronaryarterystenosis・METHODS：100casesofcoronaryheartdiseasepatientsweredividedintosingle-vesseldiseasegroup(33cases),two-vesseldisease

4、group(35cases)andmultiple-vesseldiseasegroup(32cases)accordingwiththeresultsofcoronaryarteriography.Thenormalcontrolgroup(30cases)wassetupatthesametime・DetermineandcomparetheAASI,MAUofgroups・TheextentofcoronaryarterystenosiswassignifiedwithGensiniscore・TherelationshipofAASI,MAU

5、andGensiniscorewasevaluated・RESULTS：TheAASI>MAUofmultiple-vesseldiseasegroupwere0.7±0.1,(93.4±21.3)mg/L,respectively；theAASI>MAUoftwo-vesseldiseasegroupwere0.6±0.2,(70.7±20.2)mg/L,respectively；theAASI>MAUofsingle-vesseldiseasegroupwere0.4土0.1,(36.5+13・4)mg/L,respectively.TheAAS

6、RMAUofthreediseasegroupsweresignificantlyhigherthannormalcontrolgroup(P<0.05)・Anytwodiseasegroupsofthemisstatisticallydifferent(P<0.05)・ThereweresignificantpositivecorrelationbetweenGensiniscoreandAASI,MAU(r二0.674,P<0.01；r二0.732,P<0.01)・CONCLUSION：TheAASI>MAUlevelsincreasedwith

7、theincreaseofthecoronaryarterylesioncountsandtherewerepositivecorrelationbetweentheextentofcoronaryarterystenosisandAASI>MAUlevels・KEYWORDS：AmbulatoryArterialStiffnessIndex(AASI)；microalbuminuria(MAU)；coronaryarterystenosis；relationship冠状动脉粥样硬化性心脏病是冠状动脉血管发生动脉粥样硬化病变而引起血管腔狭窄或阻塞，造

8、成心肌缺血、缺氧或坏死而导致的心脏病，常常被称为“冠心病”。冠状动脉内脂肪不断沉积逐渐形成斑块的过程称为冠状