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1、BioInformatics(1)WhatisLifeAllAbout:Self-compiling&self-assemblingComplementarysurfacesWatson-Crickbasepair(NatureApril25,1953)LifeSciencevsComputingWheredoparasitescomefrom?(computer&biologicalviralcodes)Over$12billion/yearoncomputervirusesLoveBugSetdirtemp=3Dfso.GetSp
2、ecialFolder(2)Setc=3Dfso.GetFile(WScript.ScriptFullName)c.Copy(dirsystem&"MSKernel32.vbs")c.Copy(dirwin&"Win32DLL.vbs")c.Copy(dirsystem&"LOVE-LETTER-FOR-YOU.TXT.vbs")regruns()html()spreadtoemail()listadriv()20Mdead(worsethanblackplague&1918Flu)AIDS-HIV-1Polymerasedru
3、gresistancemutationsM41L,D67N,T69D,L210W,T215Y,H208YPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPVNPYDTPVFAIKKKNSDKWRKLVDFRELNKRTQDFCEVConceptComputersOrganismsInstructionsProgramGenomeBits0,1a,c,g,tStablememoryROM,Disk,tapeDNAActivememoryRAMRNAProcessingCPU/Comp
4、ilerenzyme/RibosomeEditingEditortRNAEnvironmentSockets,peopleWater,salts,heatI/OAD/DAproteinsMonomerMineralsNucleotidePolymerchipDNA,RNA,proteinReplicationCut/PasteDNAreplicationSensor/InscannerChem/photoreceptorExcitingLife??ofRNA-basedlife:C,H,N,O,PUsefulformanyspecie
5、s:Na,K,Fe,Cl,Ca,Mg,Mo,Mn,S,Se,Cu,Ni,Co,SiElementsTheFourNucleosidesofDNAdAdGdCdTAnucleosideisasugar,heredeoxyribose,plusabasedA=deoxyadenosine,etc.PYRIMIDINESPURINESAdenineGuanineThymineCytosineUracilBASESBasePairingAnucleotideisaphospate,asugar,andapurineorapyramidineb
6、ase.Themonomericunitsofnucleicacidsarecallednucleotides.ChromosomesGenomeandgeneNucleicacidandproteinsNucleotidecodesAminoacidcodesStandardGeneticCodeSchematicillustrationofaplantcell(HomeforDNA)HistoryofstructuredeterminationfornucleicacidsandproteinsHumanchromosomes:i
7、diogramsX-linkedrecessivedisorder.Theinheritancepatternisshownfor arecessivegeneonthechromosomeX,designatedinbold.MaleXY(normal)FemaleXX(normal)FemaleXX(normal)FemaleXX(normal)MaleXY(normal)MaleXY(affected)ReductionisticandsyntheticapproachesinbiologyBiologicalSystem(Or
8、ganism)BuildingBlocks(Genes/Molecules)SyntheticApproach(Bioinformatics)ReductionisticApproach(Experiments)Basi
