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时间:2020-02-28
《诊断超声联合微泡对兔VX_2肿瘤的血流增强效应.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、临床超声医学杂志2017年4月第19卷第4期JClinUltrasoundinMed,April2017,Vol.19,No.4·217··实验研究·诊断超声联合微泡对兔VX2肿瘤的血流增强效应乔学研陈重益磋高文宏高顺记刘政摘要目的探讨不同机械指数(MI)的诊断超声联合微泡对兔VX2肿瘤的血流增强效应。方法选取健康雄性新西兰白兔40只,采用单侧大腿内侧瘤组织块接种法接种VX2肿瘤,造模成功后将其随机分为实验1组(MI=0.3)、实验2组(MI=0.7)、实验3组(MI=1.4)及对照组,每组各10只。抽取0.2ml“脂氟显”用5.0ml生理盐水稀释后经耳缘静脉通
2、道匀速推入,同时分别经不同机械指数辐照肿瘤,对照组予以超声假照,时间均为5min。储存治疗前后动态造影图像,并用造影分析软件分析,记录峰值强度(PI)和曲线下面积(AUC)。结果实验1组、实验3组治疗前后PI比较差异均有统计学意义(P=0.028、0.018),实验2组、对照组治疗前后PI比较差异无统计学意义(P=0.994、0.978);实验3组治疗前后AUC值比较差异有统计学意义(P=0.009),实验1、2组及对照组治疗前后AUC值比较差异均无统计学意义(P=0.099、0.497、0.898)。结论低能量诊断超声(MI=0.3)联合微泡可丰富兔VX2肿瘤
3、血供,高能量诊断超声(MI=1.4)可减少血流灌注。关键词诊断超声;微泡;血流增强效应;VX2肿瘤,兔[中图法分类号]R735.7;R445.1[文献标识码]ADOI:10.16245/j.cnki.issn1008-6978.2017.04.001VasculareffectofrabbitVX2tumorinducedbydiagnosticultrasoundwithmicrobubblesQIAOXueyan,CHENZhong,YICuo,GaoWenhong,GaoShunji,LIUZhengDepartmentofUltrasound,Xinqi
4、aoHospital,ThirdMilitaryMedicalUniversity,Chongqing400037,ChinaABSTRACTObjectiveToinvestigatethedifferentvasculareffectofrabbitVX2tumorinducedbydifferentmechanicalindex(MI)ofdiagnosticultrasoundcombinedwithmicrobubbles.MethodsFortyrabbitswithVX2tumorweretreatedbydiagnosticultrasoundw
5、ithdifferentMI(0.3,0.7,1.4)withmicrobubblesasexperimentgroup(experimentgroup1,2,3)andnegativecontrolwithoutanytreatment(controlgroup),eachgroupincluded10rabbits.0.2mlmicrobubblesin5.0mlnormalsalinewasusedasatherapeuticdose,thetreatmenttimewas5min.Thetumorbloodperfusionwasimagedwithco
6、ntrast-enhancedultrasoundbeforeandaftertreatmentwhichwereanalyzedbythecontrastanalysissoftware,thepeakintensity(PI)andtheareaundercurve(AUC)wereobtained.ResultsThereweresignificantdifferencesofPIbeforeandafterthetreatmentinexperimentgroup1andexperimentgroup3(P=0.028,0.018),andPIweren
7、otstatisticallysignificantbetweenexperimentgroup2andcontrolgroupbeforeandafterthetreatment(P=0.994,0.978).TheAUCwassignificantlydifferentbeforeandafterthetreatmentintheexperimentgroup3(P=0.009),whiletherewerenostatisticalsignificanceofAUCbeforeandafterthetreatmentinexperimentgroup1,2
8、andcontrolgr
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