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1、三种光疗法治疗寻常性瘗疮疗效观察［摘要］目的：评价光动力学疗法(PDT),强脉冲光(IPL)和红蓝光(LED)治疗中、重度寻常性痙疮的疗效。方法：将90例中、重度瘗疮患者随机分为三组:PDT治疗组，IPL治疗组和LED红蓝光治疗组。分别于治疗前、治疗中期(治疗1个月)和末次治疗结束后评价疗效。结果：治疗中期评价时，PDT、IPL.LED治疗组总有效率分别为93.3%、60.0%和36.7%,平均皮损减少率分别为90.4%、69.0%和39.8%。要达到炎症性皮损痊愈，PDT组平均需要(3±1.52)个治疗周期,IPL组(6±2.15)个治疗周期,LED组(9±3.34)个治疗
2、周期。结论：光疗法治疗中、重度瘗疮疗效显著,PDT组疗法效果优于IPL和LED组，副作用少，有很好应用前景，而长期疗效有待进一步观察。［关键词］光动力学疗法;强脉冲光;红蓝光;寻常性瘗疮［中图分类号］R75&73+3［文献标识码］A［文章编号］1008-6455(2010)10-1515-03EffectivenessofthreephototherapyinthetreatmentofacnevulgarisLIULi-hong,WANGCong-min,FANXin,YAOMei-hua,SUNWei-xin,YANGRong-ya(DepartmentofDermato
3、logy,GeneralHospitalofBeijingMilitaryRegionofPLA,Beijing100125,China)Abstract：ObjectiveToevaluatetheeffectivenessofphotodynamictherapy(PDT),intensepulsedlight(IPL)andlight-emittingdiode(LED)phototherapyforthetreatmentofmoderatetosevereacnevulgaris・Methods90patientswithmoderatetosevereacnewe
4、rerandomlydividedinto3equalgroups：ALA-PDTgroup,IPLgroup,blue-redcombinationLEDgroup.Clinicalassessmentswereconductedbeforestartingtreatment,at1monthasamidpointevaluation,andafterthefinaltreatmentsession.ResultsAtthemid-pointevaluation,incaseofPDT,IPLandLEDgroups,theeffectiveratewere93.3%,60
5、.0%,36.7%,respectively,andthepercentreductionswere90.4%,69.0%,39.8%,respectively.PatientstreatedwiththePDTreacheda^90%clearanceoftheirinflammatorylesionsafterameanof3土1.52sessions,whilepatientstreatedwithIPLrequiredameanof6±2.15sessions・PatientstreatedwiththeLEDrequiredameanof9±3.34sessions
6、・ConclusionsPhototherapyiseffectivetreatmentoptionformoderatetosevereacnewithmildsideeffects・EffectivenessofPDTisthebestinthethreegroup・Vaiidatesfurtherstudiestoevaluatetreatmentsforalongereffectives・Keywords：photodynamictherapy；intensepulsedlight；light-emittingdiode；acnevulgaris寻常性痙疮为炎症反应引
7、起的丘疹、脓疱、结节，伴发或不伴发非炎症性粉刺，好发于青春期，轻者可为生理性粉刺，重者可因炎症有碍面部美观。目前，痙疮的治疗方法很多,抗生素和维A酸类药物是其主要治疗方法，但疗效不稳定。光疗是一种有效的治疗寻常性痙疮的新方法，研究显示可见光的光疗，红蓝光对炎症性痙疮具有明显的治疗效果，副作用小［1］。吓咻在IPL发射谱内有小的吸收峰，以不同均质的组织为靶点，光可选择性被吸收,IPL可作为治疗痙疮的光源⑵。本研究旨在评价PDT、IPL、LED光疗治疗中、重度寻常性痙疮的疗效。1材料和方法1.1仪器及参数：
