抗原受体的多样性.ppt

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1、BASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITY免疫细胞发育与抗原受体的多样性陈宗德郑州大学基础医学院微生物学与免疫学教研室免疫细胞（immunocyte）是指参与免疫应答或者与免疫应答有关的细胞medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITY•固有免疫细胞:造血干细胞、中性粒细胞、单核巨噬细

2、胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、树突状细胞、NK细胞、NKT细胞、T细胞、B1细胞•特异性免疫细胞:T淋巴细胞、B淋巴细胞T、B淋巴细胞表面具有抗原受体，识别抗原后能活化、增殖分化，介导特异性免疫应答，又称其为免疫活性细胞（immunecompententcell，ICC）medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITY

3、免疫细胞的种类提出两个问题：1.在体内，具有特异性识别抗原表位的分子有哪些？抗体/免疫球蛋白（antibody/immunoglobulin)B细胞受体（Bcellreceptor,BCR)T细胞受体（Tcellreceptor,TCR)medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITY提出两个问题：2.在体内，淋巴细胞克隆的总数在1

4、012以上，但人体所携带的基因总数只有3×104～5×104，那么，淋巴细胞如何制造出众多不同特异性的抗原识别分子？medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITY要点1.免疫细胞的发育及抗原受体的表达2.TCR/BCR基因结构以及抗原受体的多样性机制3.TCR/BCR在T/B淋巴细胞发育中的作用medicalimmunologyCHEN

5、ZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITYBCR及TCR分子的结构CHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITYmedicalimmunologyIg、BCR、TCR结构示意图medicalimmunologyCHENZONGDE

6、DEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITYB细胞和T细胞受体多样性的特点T、B淋巴细胞抗原受体，具有一个细胞克隆表达一种受体的特性。人体内淋巴细胞克隆总数达1012以上，因此淋巴细胞识别抗原具有多样性。medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEO

7、FZHENGZHOUUNIVERSITY010203040506070809010011012013014015016017018019020021050403020100CDR1CDR2CDR3抗体分子的多样性Igl链的氨基酸序列酸残基的变异率相应位置上氨基50403020100010200405060708090100110TCRVa区氨基酸序列CDR1CDR2相应位置上氨基酸残基的变异率CDR3medicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIM

8、MUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUUNIVERSITYTCR分子的多样性BCR与TCR的立体结构BCRTCRmedicalimmunologyCHENZONGDEDEPARTMENTOFMICROBIOLOGYANDIMMUNOLOGYBASICMEDICALSCIENCECOLLEGEOFZHENGZHOUU