英语杨靖.ppt

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1、学号：2014103020027姓名：杨靖TheSignalingPathwaysinCerebralIschemia-inducedneurogenesisNeurogenesisintheadultbrainSVZ:thesubventricularzone.physiologicalAction:odordiscriminationolfactorymemeorySGZ:thesubgranularzone.physiologicalAction:learning,memoryandneuropsychiatricdisordersNeurogenesi

2、sinCerebralIschemianeuralstemcells;neuralprogenitorcells;neuroblastsTheShhSignalingPathwayinIschemia-inducedNeurogenesisTheShhreceptorsPtcandSmoareexpressedintheadulthippocampusandinprogenitorsderivedfromthisregion.ExogenousShhincreasesneurogenesisintheSVZ.TheShhpathwayalsomediatess

3、troke-inducedneurogenesis.ThemiR-17-92clusterintheShhsignalingpathway.TheShhSignalingPathwayinIschemia-inducedNeurogenesisTheNotchSignalingPathwayinCerebralIschemia-inducedNeurogenesisVariousstudieshaveshownthatcomponentsoftheNotchpathwayareexpressedintheSVZandSGZoftheadultmammalian

4、brain.Intheischemicbrain,activationoftheNotchpathwayincreasesneuralprogenitorcellproliferatio.miR-124aintheNotchsignalingpathway.TheNotchSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheBMPSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheBMPSignalingPathwayandNoggini

5、nCerebralIschemia-inducedNeurogenesisBMPsarenegativelyregulatedbyNoggin.TheWntSignalingPathwayinCerebralIschemia-inducedNeurogenesisTheWntSignalingPathwayinCerebralIschemia-inducedNeurogenesisSeveralstudieshaveaddressedtheroleofWntsignalinginadultneurogenesis.Cerebralischemiachanges

6、expressionofWntandBMPfamilygenesinSVZneuralprogenitorcells.NeurotrophicfactorsinCerebralIschemia-inducedNeurogenesisThankyou