磺胺嘧啶钠在家兔药动学参数的测定与计算.pdf

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1、磺胺嘧啶钠在家兔药动学参数的测定与计算磺胺嘧啶钠在家兔药动学参数的测定与计算实验一：SD-Na标准曲线的制备及回归方程的计算实验一：SD-Na标准曲线的制备及回归方程的计算管号012345管号012345X=SD-Na含量01020304050X=SD-Na含量01020304050Y=OD52500.140.2370.3080.4650.584Y=OD52500.140.2370.3080.4650.584SD-Na标准曲线SD-Na标准曲线OD525OD525y=0.0112x+0.0120y=0.0

2、112x+0.01200.80.8R^2=0.9841R^2=0.98410.60.60.4系列1系列10.4线性(系列1)线性(系列1)0.20.20SD-Na含量（ug）0SD-Na含量（ug）01020304050600102030405060实验二：SD-Na血药浓度测定实验二：SD-Na血药浓度测定X-时间（min）OD525SD含量（ug）Y-血药浓度（ug∕ml）LgYX-时间（min）OD525SD含量（ug）Y-血药浓度（ug∕ml）LgY0000000050.23920.2678571

3、4202.67857142.30680850.23920.26785714202.67857142.306808100.13210.71428571107.14285712.029963100.13210.71428571107.14285712.029963150.26222.32142857223.21428572.348722150.26222.32142857223.21428572.348722200.216.78571429167.85714292.22494200.216.785714291

4、67.85714292.22494300.1179.37593.751.971971300.1179.37593.751.971971600.13711.16071429111.60714292.047692600.13711.16071429111.60714292.047692相关参数相关参数SD-Na血药浓度关系y=-0.0041x+2.2505-1SD-Na血药浓度关系LnYK(min)0.0094423y=-0.0041x+2.2505-1R^2=0.2635LnYK(min)0.0094423

5、R^2=0.26352.4t(min)73.39313512.42.31/2t1/2(min)73.39313512.32.2C0(ug/ml)178.0327912.22.1C0(ug/ml)178.032791系列12.12系列1线性(系列1)Vd=DO/C0(ml/kg)2.2467771121.9线性(系列1)Vd=DO/C0(ml/kg)2.246777111.91.8时间（min）C1(ml/kg/min)0.021214741.8C1(ml/kg/min)0.021214741.7时间（mi

6、n）1.7020406080AUC18854.812020406080AUC18854.812DO(ug/kg)400DO(ug/kg)400