小眼畸形相关转录因子.pdf

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1、b-White™InnovationinwhiteningWhylaunchingβ-White™?–Innovation创新•Huge(andgrowing)marketpotential市场潜力巨大（且不断扩张）•Firsttomarket!首次面市•Mechanismofaction:abreakthrough!作用机理：巨大突破！–Performance性能•UnipexInnovationsknowledgeinwhiteningmarket在美白市场的经验•FullClinicalEfficacy完整

2、的临床测试•Biomimeticpeptide仿生肽–Safety安全•Targetedmechanismofaction靶向性作用机理•Excellentsafetyprofile极佳的安全性•Batchtobatchquality严格的质量控制Agenda-Whiteningpeptide•IntroductiononWhitening,brightening,lightening(BWL)market美白、亮肤、淡肤市场简介•InVitroassays体外测试–TGF-breceptorbindingTGF

3、-b受体结合度–Inhibitionoftheconstitutiveproductionofmelaninpathway抑制构成性黑色素沉着通道:TRP1–TRP2–tyrosinase–Inhibitionofthetyrosinaseactivity抑制酪氨酸酶活性–Inhibitionofmelaninsynthesis抑制黑色生成–Morphologicalstudiesonmelanocytes黑素细胞形态研究•Clinicalefficacy临床功效–Whiteningandlighteningef

4、ficacy美白亮肤功效•Tolerancestudies皮肤耐受性测试•Applications应用•Conclusion总结Whyareweusingskinwhitening?•Whiter/lighterskintone美白/亮肤–InAsia,lighterandevencomplexionisassociatedwithhighersocialstatus(wealth&education)andadarkercomplexionhasbeenassociatedwithpeoplewhoworkin

5、thefieldandaremoreexposedtothesun.在亚洲，肤色白皙均匀表示高的社会地位（财富和知识）；而暗淡的肤色往往会与体力劳动或者社会下层发生联想。Vichy®•Lightenage-spotandhyper-pigmentation淡化老年斑及色素沉着过度–InNorthAmericaandEuropeskinwhiteningisseenmoreasapartofanti-agingtreatment,tohideunwantedsignsofaginglikeagespot,unhea

6、lthylife-styleandpollutionfromtheskin在北美及欧洲，皮肤美白主要归于抗衰老范畴，即隐藏衰老迹象，如老年斑、不健康的生活习惯及污染等在皮肤留下的印迹Focusonb-White™SkinPigmentationPigmentationisdeterminedbytheamount&typeofmelaninintheskinItcanbeinfluencedby黑色素数量及种类决定皮肤肤色:1-Geneticconstitutivepigmentation(African,Asi

7、an,Caucasian)组成性色素沉着（非洲，亚洲，白种人）2-Facultativepigmentation:UVexposureviaα-MSHactivation兼性色素沉着：UV暴晒下激发促黑因子活性SkinPigmentationActorsMainActor主导因素：MITF(microphtalmia-associatedtranscriptionfactor)MITF（小眼畸形相关转录因子）•Roleinconstitutivepigmentation:responsibleofphototyp

8、e构成性色素沉着：负责肤色•Roleinfacultativepigmentation:regulatesskinresponsetoUV兼性色素沉着：调控由UV引起的肤色变化Ex:Representsthemaestrointheorchestra如乐队的指挥MITFItdirectsthemusicianstoproducethemusic负责指挥乐手，创造乐曲Sec