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1、HIV-2isolateALIfromGuinea-Bissau,completegenomeLOCUSAF08233910353bpDNAlinearVRL13-DEC-1998DEFINITIONHIV-2isolateALIfromGuinea-Bissau,completegenome.ACCESSIONAF082339VERSIONAF082339.1GI:4007991KEYWORDS.SOURCEHumanimmunodeficiencyvirus2(HIV-2)ORGANISMHumanimmunodeficiencyvirus2Viruses;Retr
2、o-transcribingviruses;Retroviridae;Orthoretrovirinae;Lentivirus;Primatelentivirusgroup.REFERENCE1(bases1to10353)AUTHORSAzevedo-Pereira,J.M.,Goncalves,J.,Freitas-Vieira,A.,Vital,J.,Santos-Costa,Q.andMoniz-Pereira,J.TITLECompletenucleotidesequenceofHIV-2ALI,alowinfectiousisolatewithrestric
3、tedtropismtoprimaryCD4+cellsJOURNALUnpublishedREFERENCE2(bases1to10353)AUTHORSAzevedo-Pereira,J.M.,Goncalves,J.,Freitas-Vieira,A.,Vital,J.,Santos-Costa,Q.andMoniz-Pereira,J.TITLEDirectSubmissionJOURNALSubmitted(04-AUG-1998)Microbiology,FacPharmacyofLisbon,AvenueForcasArmadas,Lisbon1600,P
4、ortugalFEATURESLocation/Qualifierssource1..10353/organism="Humanimmunodeficiencyvirus2"/proviral/mol_type="genomicDNA"/strain="HIV-2ALI"/isolate="ALI"/db_xref="taxon:11709"/country="Guinea-Bissau"/note="primaryisolaterecoveredfromasymptomaticpatient;differentiatingbiologicalcharacteristi
5、cscomparedtootherHIV-2:lowinfectivityinvitro,persistentincapabilitytoinducesyncytiaformation,extremelynarrowcellularhostrange;viruswasonlypassagedtwiceinhumanPBMCbeforechromosomalDNAfrominfectedcellswasharvested;directPCRwasperformedtoobtainthetotalproviralDNAinfouroverlappingfragmentsth
6、atwereclonedintoplasmidvectorpCR3;bothstrandsofproviralDNAwerecompletelysequenced;theHIV-2ALIgenomerevealsasimilarlocalizationoftheopenreadingframesforstructural,regulatoryandaccessorygenes,comparedtootherHIV-2viruses"repeat_region1..850/note="5'longterminalrepeat"/rpt_type=long_terminal
7、_repeatgene1096..2661/gene="gag"CDS1096..2661/gene="gag"/note="encodesstructuralproteinsofHIV-2ALInucleocapside"/codon_start=1/product="gagprotein"/protein_id="AAC95340.1"/db_xref="GI:4007992"/translation="MGARNSVLRGRKADELERIRLRPGGKKKYQLKHIVWAANELDRFGLAESLLESKEGCQRILKVLEP
