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时间:2019-10-18
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1、1.[MinimumInhibitoryConcentration(MIC)
2、isthelowestconcentrationofanantimicrobialthatwillinhibitthevisiblegrowthofamicroorganismafterovernightincubation.MICisgenerallyregardedasthemostbasiclaboratorymeasurementoftheactivityofanantimicrobialagentagainstanorgani
3、sm・最低抑菌浓度(MIC):在体外培养细菌18・24h后能抑制培养基内细菌生长的最低药物浓度。2.MinimumBactericidalConcentration(MBC)
4、isthelowestconcentrationofantibioticrequiredtokillanorganism.最低杀菌浓度(MBC):在体外试验中,能够瑟培养基内细菌的最低药物浓度。3・Phaonacokineticsl:whatthebodydoestothedrugPharmacodynamics
5、:whatthedrugd
6、oestothebodyPharmacokinetics;ADMEPharmacokinetics:whatthedoestothedrugPharmacodynamics:whatthedrugdoestothe—theactionsofdrugswithinthebodyPharmacodynamics—themechanismsofdrugaction—therelationshipbetweendrugconcentrationandeffect4.Half-life♦alsorefersto^elimi
7、nationhalf-life”.♦thetimeittakesforadrugtolosehalfofitsplasmaconcentratior♦animportantpharmacokineticparameter♦usuallydenotedbytheabbreviationtl/25」First,passmetabolismFirst-passeffectorFirst-passeliminationAphenomenonofdrugmetabolismwherebytheconcentrationof
8、adrugisgreatlyreducedbeforeitreachesthesystemiccirculation.某些吩物首次通过肠壁或经门静脉进入肝脏时被其中的酶所代谢致使进入体循环的药量减少的一种现象6.BioavailabilityAmeasurementoftheextentofatherapeuticallyactivedrugthatreachesthesystemiccirculationandisavailableatthesiteofaction.oneoftheprincipalpharm
9、acokineticpropertiesofdrugs经任何给药途径给予一定剂量的药物后到达全身血液循环内药物的百分率7.Areaundertheconcentration/timecurve(AUC)
10、Themostreliablemeasureofbioavailabilitv.Directlyproportionaltothetotalamountofunchangeddrugthatreachesthesystemiccirculation.Calculatingtherelativeefficiency
11、ofdifferentdrugproducts血药浓度•时间曲线下面积:血药浓度随时间变化的积分值,与吸收后进入体循环的药量成正比,反映进入体循环药物的相对j1.Duodenalulcerdisease•active活动性十二指肠溃疡2.Erosiveesophagitis腐蚀性食道炎3.Erosiveesophagitis―astroesophagealrefluxdisease腐蚀性食道炎-胃食管返流疾病4.Gastrichypersecretion胃液分泌过多5.Gastriculcer,active,be
12、nigh良性活动性胃j贵疡6.Gastroesophagealrefluxdisease—heartburn胃食管返流疾刁芮-烧#0?7.Helicobacterpylorigastrointestinaltractinfection幽门虫累和:菌胃丿扬道?咚染8.Recurrentduodenalulcer复发性十二指肠溃疡9.Stressulcer应激件溃疡9.App
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