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《自体分选造血干细胞和异体脐带间充质干细胞移植治疗神经系统变性疾病_王黎明》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、中国组织工程研究与临床康复第15卷第10期2011–03–05出版JournalofClinicalRehabilitativeTissueEngineeringResearchMarch5,2011Vol.15,No.10自体分选造血干细胞和异体脐带间充质干细胞移植治疗神经系统变性疾病★◆1111122王黎明，周建军，白雯，白槟，李建军，王立华，刘拥军Autologoushematopoieticstemcelltransplantationandallogeneicumbilicalcordmese
2、nchymalstemcelltransplantationinthetreatmentofneuraldegenerativediseases1111122WangLi-ming,ZhouJian-jun,BaiWen,BaiBing,LiJian-jun,WangLi-hua,LiuYong-junAbstract1BACKGROUND:Autologoushematopoieticstemcelltransplantation(AHSCT)andallogeneicumbilicalcordmes
3、enchymalstemCellTherapyCenter,cell(UC-MSC)technologyareappliedinclinic,tryingtofindanewfeasiblemethodofthetreatmentofneuraldegenerativeThe323HospitalofChinesePLA,Xi’andisease.710054,Shaanxi+OBJECTIVE:TostudythefeasibilityofAHSCTCD34andUC-MSCinthetreatmen
4、tofneuraldegenerativedisease.Province,China;2METHODS:Atotalof21patientswithneuraldegenerativediseasewereselected,including15caseswithmotorneurondiseaseNationalStateKey(MND),6caseswithspinocerebellarataxia.Avolumeof4mLUC-MSCorAHSCTsolutionwasinjectedintos
5、ubarachnoidspaceLaboratoryof7Hematology,Institutethroughlumbarpuncture;thenumberofinjectedcellswas1.0×10eachtime.At3monthsfollowingstemcellstherapy,allofHematology,patientswerescored.ChineseAcademyofRESULTSANDCONCLUSION:In15patientswithMND,thetotaleffect
6、iveratewas80%.ThereweresignificantdifferencesMedicalSciences,betweentheacutelateralsclerosis(ALS)functionalratingscaleandtheself-assessmentquestionnairescoresbeforeandafterTianjin300020,Chinatreatment(P<0.05).Sixcaseswithspinalcerebellarataxiaunderwentin
7、ternationalcooperativeataxiaratingscale(ICARS).Thegradeofdiseaseconditionwasreducedin4cases;thetotaleffectiveratewas77%.Fourofthe21caseshadmildintracranialWangLi-ming★,hypotensionheadache(afterlumbarpuncture).Twoofthe14patientswiththetreatmentofUC-MSChad
8、transientfeverat2Master,Chiefhoursaftertreatment.Theremainingpatientshadnosignificantadversereactionsaftertreatment.Theresultsprimarilyphysician,CellTherapyCenter,ThedemonstratedthattheAHSCTandUC-MSChaveapositiveclinicalef
