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1、血清铁蛋白、叶酸检测在血液系统恶性肿瘤患者中的临床价值张秀姐'2于文征彳1.滨州医学院256603,2.山东省巨野县人民医院血液科274900,3.滨州医学院附属医院血液科256603【摘要】目的探讨血清铁蛋白(Serumferritin,SF)、叶酸在血液系统恶性肿瘤患者诊断及预后中的临床价值。方法采用放免法测定97例血液系统恶性肿瘤患者化疗前后铁蛋白、叶酸的水平，分别观察对照组、治疗前、治疗后缓解组、部分缓解组及未缓解组血清铁蛋口、叶酸结果，进行组间比较。观察并比较不同铁蛋口水平下疾病的缓解率。结果所观察的97例患者病程的各阶段均存在不同程度的铁蛋白增高、叶酸减低。尤以治疗前及治疗后未缓解
2、组明显；治疗后完全缓解组SF、叶酸均有明显变化，与治疗前均值相比(P<0.01),但仍未恢复止常水平；经治疗后部分缓解组SF、叶酸与正常对照组及治疗前均值比较均有统计学意义(PvO.Ol)；同时治疗前SF小于600ng/ml的患者常规化疗缓解率明显高于人于600ng/ml的患者(PvO.Ol)。结论血清铁蛋口及叶酸可作为血液系统恶性肿瘤学的指标，其测定不仅有助于诊断与预后的判断，还能够初步进行疗效评价，指导化疗方案的选择及调整。【关键词】铁蛋H；叶酸；血液系统恶性肿瘤ClinicalsignificanceofdetectionofSerumferritinandfolateinpatient
3、swithhematologicalmalignantdiseaseZhangXiu-juan1YuWen-zheng31.BinzhouMedicalUniversity,Binzhou,2566032.DepartmentofHematology,JuyeCountyPeopleJs,Shandong,Heze2749003.DepartmentofHematology,AffiliatedHospitalofBinzhouMedicalUniversity,Binzhou,256603[Abstract】ObjectiveToinvestigatetheclinicalvalueofs
4、erumferritin(SF)andfolatedetectioninthediagnosisandprognosisjudgmentofthcpatientswithhematologicalmalignantdisease.MethodsAdoptradioimmunoassaytodetectserumferritinandfolateof97patientswithhematologicalmalignanciesindifferentperiod,serumferritinandfolatewereobservedseparatelyinControlgroup、no-treatm
5、entgroup>remissiongroupnPartialremissiongroupandnon-remissiongroup,theseresultsarecomparedbetweengroups.Toobserveandcomparetheremissionrateofdiseaseindifferentferritinlevel.ResuItsTherearedifferentdegreesofserumferritinincreaseandfolatereduceineverystageofthe97通讯作者:于文征,E-mail：bzywz2009@163.compatien
6、tswithhematologicalmalignanttumorpatientsobserved.Especiallyinno-treatmentgroupandnon-remissiongroup;CompleteremissiongrouphaveobviouschangesinSFandfolate,Comparedwithbeforetreatment(P<0.01),butnotbacktonormal;PartialremissiongroupcomparedwithbeforetreatmentandControl(P<0.01);PatientswithlowerSF(<60
7、0ng/L)acquiredhigherremissionratethanothers(P<0.01)。ConclusionSerumferritinandfolatecanbeusedasindicatorsofhematologicalmalignantdisease,theyarehelpfulnotonlytodiagnosisandprognosis,Alsotopreliminarye
