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1、胡颓子根的化学成分研究刘祥，丁骁，欧阳明安，任青云(福建农林大学生物农药与化学生物学教育部重点实验室，福州350002)摘耍：药用梢物胡颓子为胡颓子科，胡颓子属植物，主耍分布于长江流域以南各省区。该属植物含有挥发油、帖类、生物碱、黄？M等化学成分，药理活性主要冇降血耕，降血脂、抗脂质氧化、抗炎钺痛、免疫等。基于以往的报道，对胡颓子根部化学成分的研究很少，为推动新型药物的利用和开发，本文以采白泉州清源山的胡颓子根为研究对彖，运用D101、SephadexLH-20.MCI柱色谱法、硅胶柱色谱法及半制备HPLC进行分离纯化到
2、六种分离物，经核磁共振波谱解析，分別鉴定为：表儿茶素(1),1,4,9-三疑基-紫罗兰醇(2),3’■甲氧基•懈皮素-3-O-P-D-1B萄糖伏(3),3'•甲氧基•懈皮素・3・O・ct・L・鼠李糖-(l->2)-p-D-葡萄糖貳(4),2•甲氧基苯酚-4-O-a-L-阿拉伯糖・(1->6)作D-半乳糖爪(5),对轻基苯甲酸丁酯(6)3,4-二甲氧基-5巽基■苯酚-l-0-a-D-阿拉伯Wf-(1^6)-p-D-匍萄糖貳(7)。关键词：胡颓子；胡颓子科；胡颓子屈；化学成分；核磁共振中图分类号:R284.2Studyonc
3、hemicalconstituentsofrootsofElaeagnuspungensLIUXiang,DINGXiao,OUYANGMing-an,RENQingyun(KeyLaboratoryofBio-PesticideandChemistry・Biology,MinistryofEducation,FujianAgricultureandForestryUniversity,Fuzhou350002丿Abstract:MedicinalplantElaeagnuspungenswhichbelongstoth
4、efamilyElaeagnaceae,Elaeagnus,mainlydistributedintheprovincessouthoftheYangtzeRiver.Thegenuscontainingvolatileoil，terpenoids^alkaloids,flavonoidsandotherchemicalconstituents.Itspharmacologicalactivitiesmainlyhavehypoglycemic,hypolipidemic,antilipidoxidation,anti-
5、inflammatoryandanalgesic^immune^etc.Basedonpreviousreports,fewstudiesonchemicalconstituentsofElaeagnusrootDothefollowingworktopromotetheuseanddevelopmentofnewdrugs.ChemicalinvestigationoftheextractsofElaeagnuspungensrootwhichwerecollectedfromtheQingyuanMountainof
6、quanzhoubyusingvariouschromatographictechniquessuchasD101,SephadexLH-20columnchromatography,MCI,silicagelcolumnchromatography^andsemi-preparativeHPLC.SixcompoundswereobtainedandthenbyNMRspectralanalysiswereidentifiedasepicatechin(1),1,4,9-trihydroxy-megastima(2),
7、3-methoxy・quercetin・3・O•卩・D・glucopyranoside(3)93-methoxy・quercetin・3・O・(x・L-rhamnose・(l—>2)■卩・D-gIucopyranoside(4),2-methoxyphenol-4-O-a-L-arabinose-(1—>6)-p-D-galactoside(5),Butylparaben(6),3,4-dimethoxy-5-hydroxy-phenol-l-0-«-D-arabinose-(1^6)-p-D-glucopyranosi
8、de(7)>Keywords:Elaeagnuspungens;Elaeagnaceae;Elaeagnus;chemicalconstituents;NMR基金项目:教育部博上点学科专项基金(20103515110007,20093515120005)；福建省H然科学基金(2012J01088)作者简介：刘祥(19
