低聚果糖通便作用探究

《低聚果糖通便作用探究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、低聚果糖通便作用探究作者:何为涛，赵鹏，刘荣珍，李凤文，姚思宇【摘要】目的研究低聚果糖的通便功能作用。方法动物实验：分别以2.5、5.0和10.0g/(kg・BW)3个剂量经口给予小鼠连续灌胃，7天后进行小肠运动实验、排便时间、粪便粒数和粪便重量的测定。结果各剂量组的墨汁推进率均高于便祕模型对照组，各剂量组的首便时间均比便秘模型对照组的缩短，而各剂量组粪便粒数均多于便秘模型对照组，且差异有显著性；人群试食试验：选择非器质性便秘者102例，分为试食组和对照组各51例，两组试验期间不改变原来的饮食习惯，正常饮食，试食组加服低聚果糖，3次/d,每次10mlo7天后，比较两组试验前后排便次数、排便状况

2、和粪便性状的变化，并测定试验前后血常规、血生化指标等。结果试验组服用后排便次数明显增加(P<；0.01),排便状况和粪便性状明显改善(P<；0.01),总有效率为92.2%(P<；0.01),且受试者的血常规、血液生化指标及其他临床检查均无异常。结论低聚果糖具有通便功能。【关键词】低聚果糖；通便；人体试验Studyontheeffectoffructooligosaccharidefacilitatingfecesexcretion【Abstract】ObjectiveTostudytheeffectoffructooligosaccharideonfacilitatingfece

3、sexcretion.MethodsInvivoanimalexperiment：intheexperiment,miceweregivenfructooligosaccharidesamplesthroughoralgavageat2.5,5.0and10.Og/(kg•BW)forsevenconsecutivedays.ThentherateofIndianinkadvancinginthesmallintestines,thetimeoffirstblackfecesexcretion,thenumberoffecesgranulesandtheweightoffecesweremea

4、sured.ResultsWefoundthattherateofIndianinkadvancinginthesmallintestinesofmicetreatedwithfructooligosaccharidewassignificantlyhigherthanthatintheconstipationcontrolgroup.Alsocomparedtotheconstipationcontrolmice,thefirstblackfecesexcretionwassignificantlyfasterinthemicetreatedwithfructooligosacharide・

5、Furthermore,micetreatedwithfructooligosacharidesamplesproducedmorefecesgranulesthanthecontrolgroup.Invivohumanstudy：102constipationpatientswererandomlydividedintotwogroups.Boththetreatedgroupandthecontrolgroupcontained51patients・Patientsmaintainedtheirregulardietthroughouttheexperiment.However,patie

6、ntsinthetreatedgroupweregiven25g/dayfructooligosaccharideforsevenconsecutivedays・Then,thefrequencyoffecesexcretion,easeoffecesexcretionandtheappearanceoffecesgranuleswereexaminedandcomparedtothatbeforetreatment.Theeffectoffructooligosaccharidetreatmentonbloodbiochemistryandbloodroutinewerealsoexamin

7、ed.ResuIts:Thefrequencyoffecesexcretioninthetreatedgroupwassignificantlyimproved(P<；0.01).Moreover,easeoffecesexcretionandtheappearanceoffecesgranuleswerealsoimproved(P<；0.01).Overall,92.2%ofthepa