Ⅰb~Ⅱb期宫颈癌先期化疗疗效探究

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1、Ib~IIb期宫颈癌先期化疗疗效探究［摘要］目的探讨1b〜lib期宫颈癌术前先期治疗疗效。方法将我院84例宫颈癌患者分三组，其中，直接手术组28例，静脉化疗组25例，介入化疗组31例。静脉化疗组与介入化疗组在术前均进行先期化疗一疗程再手术，而直接手术组未进行任何处理直接手术治疗。分析三组化疗疗效及并发症情况。结果静脉化疗组与介入化疗组宫颈癌肿块缩小在临床分期、肿块大小、病理分类、病理分化方面比较，差异均无统计学意义(P>0.05)o静脉化疗组与直接手术组不良因素、髙危因素比较，差异有统计学意义(P0.05),与介入化疗组的(704・25±43.57)mL比较，差异无统计学意义(P>

2、0.05)o宜接手术组并发症发生率与静脉化疗组及介入化疗组比较，差异均无统计学意义(P>0.05)o结论术前新辅助化疗已广泛应用于Ib〜lib期宫颈癌患者，在实际临床工作中取得了良好效果，不仅能够减少患者预后不良因素，而且对术中出血量无明显影响，术后并发症亦没有明显增加，可以提高患者5年生存率和生活质量。［关键词］宫颈癌；新辅助化疗；介入化疗；静脉化疗;先期治疗［中图分类号］R737.33［文献标识码］A［文章编号］1673-7210(2012)07(b)-0032-03ResearchofeffectsofprimarychemotherapyonIb~IIbstageofcer

3、vicalcancerSUNYalingThePeople，sHospitalofZunhuaCity,HebeiProvince,Zunhua064200,China[Abstract]ObjectiveTodiscusstheeffectsofprimarychemotherapyonIb~IIbstageofcervicalcancer・Methods84casesofpatientswithIb-llbstageofcervicalcancerinourhospitalweredividedintothreegroups：directsurgerygroup(n=28),v

4、enouschemotherapygroup(n=25)andinterventionchemotherapygroup(n二31).Patientsofthevenouschemotherapygroupandinterventionchemotherapygroupallunderwentoperationafteronecourseofprimarychemotherapy.Directsurgerygroupunderwentoperationwithoutanyprocessing.Theefficacyofchemotherapyandcomplicationsamon

5、gthethreegroupswerecompared・ResultsTherewerenosignificantdifferencesinclinicalstage,tumorsize,histologicclassification,pathologicdifferentiationoftumourreductionbetweenvenouschemotherapygroupandinterventionalchemotherapygroup(P>0.05).Thereweresignificantdifferencesinadversefactors,riskfactorsb

6、etweeninterventionchemotherapygroupanddirectsurgerygroup(P0.05)orinterventionalchemotherapygroup[(704.25±43.57)mL](P>0.05)・Therewasnosignificantdifferenceintheincidenceofcomplicationsbetweendirectsurgerygroupandvenouschemotherapygrouporinterventionalchemotherapygroup(P>0・05).ConclusionPreopera

7、tiveneoadjuvantchemotherapyhasbeenwidelyusedinIb-IIbstageofpatientswithcervicalcancerandachievesgoodresuItsinactualclinicalwork.Itnotonlycanreducetheprognosisadversefactors,butalsohasnosignificanteffectonintraoperativebloodlossandpostop