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1、复方牛胎肝提取物治疗乙型肝炎肝硬化疗效观察卢敏，毛华，黄纯炽，唐银丽，张能友，席建东【摘要】口的探讨复方牛胎肝提取物治疗乙型肝炎肝硬化患者的疗效。方法将120例乙型肝炎肝駛化患者随机分为治疗组80例和对照组40例。给予治疗组复方牛胎肝联合基础护肝治疗，对照组仅予以基础护肝治疗，疗程3个月，对比两组患者治疗前后肝功能、肝脏硬度值(LSM),以及B超检测门静脉内径、脾脏厚度、脾静脉宽度的变化。结果在3个刀治疗结束时，治疗组患者血清TBIL为(33.0±2.07)pnol/L、ALT为(3640±5.86)U/L、LSM为(1
2、0.78±1.15)Kpa,均较对照组显著下降[分别为(48.62±4.24)pmol/L、(52.60±7.3)U/L、(15.26±2.17)Kpa,P<0.05];治疗组血清ALB水平为(35.0±1.58)g/L,较对照组明显升高[(31±1.58)g/L,PV0.05];治疗组门静脉内径为(1.26±0.08)cm,脾脏厚度为(3.97±0.04)cm，脾静脉宽度为(0.87±0.02)cm,均较对照组显著降低[分别为(1.36±0.05)cm、(4.20±0.10)cm、(0・92±0・02)cm,P<0.0
3、5]。结论复方牛胎肝提取物可显著改善乙型肝炎肝駛化患者的肝功能，减轻肝纤维化程度。【关键词】肝硬化;乙型肝炎;复方牛胎肝提取物;疗效DOI：10.3969/j.issn.l672-5069.2015.02.011EfficacyofcompoundembryonicbovineliverextractinpatientswithhepatitisBrelatedlivercirrhosisLuMin,MaoHua,HuangChunchi,etal.DepartmentofGastroenterology,Zhujian
4、gHospitalAffiliatedtoSouthernMedicalUniversity,Guangzhou510282,GuangdongProvince,China[Abstract]ObjectiveToinvestigatetheeffectofcompoundembryonicbovineliverextractinpatientswithhepatitisBrelatedlivercirrhosis.MethodsOnehundredandtwentypatientswithhepatitisBinduc
5、edlivercirrhosiswererandomlydividedintotwogroups,with80intreatmentgroupreceivingcompoundembryonicbovineliverextracttabletsatthebaseofbasicliver-protectingtreatmentand40incontrolgroupreceivingthebasicliv-er-protectingtreatmentonlyfor3months.Liverfunctiontests,live
6、rstiffnessmeasurement(LSM)byFibrotouch,andportalveindiameters,spleenthicknessandsplenicveinwidthbeforeandaftertreatmentwerecomparedinbothgroups・ResultsAttheendof3-monthtreatment,scrumTBIL,ALT,andLSMvaluesinpatientsintreatmentgroupwere(33.0±2.07)(imol/L,(36.40±5.8
7、6)U/L,(10.78±1.15)Kpa,respectively,significantlydecreasedascomparedwiththoseinthecontrols[(48.62±4.24)pmol/L,(52.60±7.3)U/L,(15.26±2」7)Kpa，respectively,P<0.05forall];serumALBlevelsinpatientsintreatmentgroupincreasedsignificantlycomparedwiththatincontrols[(35.0±1.
8、58)g/Lvs.(31±1・58)g/L,P<0.05];portalveindiameters,spleenthicknessandsplenicveinwidthsremarkablydecreasedcomparedwiththoseinpatientsinthecontrolgroup[(1.26±0.08
