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1、多潘立酮联介复方阿嗪米特治疗功能性消化不良的临床分析［摘耍］冃的:评价多潘立酮片联合复方阿嗪米特肠溶片治疗功能性消化不良(FD)的临床疗效和安全性。方法:将80例功能性消化不良忠者随机分成实验纟F1和对照组，每纟R40例，实验组口服多潘立酮片和复方阿嗪米特肠溶片，对照组单独口服多潘立酮片，疗程4周。采用临床症状积分法观察各组患者上腹部烧灼感、餐后饱胀、上腹痛及暧气等症状的改善程度。结果:治疗4周后两组患者症状积分均低于治疗前，差界有高度统计学意义(P<0.01);对照组症状积分改善率低于实验纽，差异有高度统
2、计学意义(P〈0.01)。实验纽及对照纽治疗1周后总有效率分别为40.0%和32.5%,差异无统计学意义(P>0.05),但治疗4周后总有效率分别为87.5%和47.5%,差异冇高度统计学意义(P〈0.01)。治疗过程中各组均未出现严重药物副作用。结论:联合使用多潘立酮片及复方阿嗪米特肠溶片治疗功能性消化不良的临床疗效明显优丁单独使用促动力笏多潘立酗，值得临床推广。［关键词］多潘立酮;复方阿嗪米特；功能性消化不良；药物治疗［中图分类号］R57［文献标识码］A［文章编号］1673-7210(2010)01(a
3、)-022-03ClinicalanalysisofDomperidoneandCompoundAzintamideinthetreatmentoffunctionaldyspepsiaYANGLili,DUYiping,ZOUBing,HEMin,GUANXingqiu(DigestiveDepartmentofShenzhonHospitalofPekingUnivcrsily,Shenzhen518036,China)［Abstract］Objective:Toevaluatetheefficacya
4、ndsafetyofDomperidoneandCompoundAzintamideinthetreatmentoffunctionaldyspepsia.Methods:80patientswithfunctionaldyspepsiawererandomlydividedintotheexperimentalgroup(n=40)andthecontrolgroup(n=40).TheexpcrimcntalgroupwasgivenDomporidoneandCompoundAzintamide,an
5、dthecontrolgroupwasonlygivenDomperidonefor4weeks.Theimprovementofclinicalsymptomssuchasstomachburn,abdominaldistention,upperabdominalpainandeructationwereevaluatedbyclinicalsymptomscore.Results:After4weeks'treatment,theabdominalsymptomscoresofbothgroupswer
6、esignificantlylowerthanthosebeforethetreatment(P<0・01),andtheimprovemontofabdominalsymptomscoreofcontrolgroupwassignificantly1owerthanthatofexperimentalgroup(P<0.01).Thetotaleffectiveratesafter1week'streatmentofexperimentalgroupandcontrolgroupwere40.0%and3
7、2.5%respectively,andtherewasnostatisticalsignificanee(P>0.05).However,therewasastatisticalsignificanccafter4wceks，treatment,with87.5%intheexperimentalgroupand47.5%inthecontrolgrouprespective!y.Noseveresideeffectwasobservedinbothgroups.Conelusion:Combinedth
8、erapyofDomperidoneandCompoundA刁intamideismoreeffectiveinpatientswithfunctionaldyspepsiathansingleuseofmotilitymedicineDomperidone.Itdeservesclinicalexpansion・［Keywords］Domperidone;CompoundAzintamidc;Functiona
