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1、三种方法治疗瘢痕疙瘩临床疗效观察[摘要]目的:比较分析手术联合90Sr-90Y敷贴、手术联合糖皮质激素注射和局部糖皮质激素注射三种方法治疗瘢痕疙瘩的临床疗效。方法:患者分为A、B、C三组,A组行手术联合90Sr-90Y敷贴治疗:手术切除病灶,术后予90Sr-90Y敷贴治疗,每疗程剂量900cGy,小剂量分次,100〜200cGy/次,隔日一次,每5次为一疗程,共2〜3个疗程。:B组行手术联合糖皮质激素注射治疗:手术切除病灶,术中注射醋酸曲安奈德注射液,术后每两周1次,连续2〜4月。C组:皮损内注射醋酸曲安奈德注射液,每两周1次,连续3〜6月。结果:A、B、C三
2、组总有效率分别为97%,80%和53%。A与B组比较无显著差异(P>0.05)oA、B组分别与C组间比较均有显著性差异(P<0.05)o结论:A、B组两种综合治疗方法均较C组单一治疗疗效更为满意。[关键词]瘢痕疙瘩;手术;90Sr-90Y;曲安奈德[中图分类号JQ813.1[文献标识码]A[文章编号]1008-6455(2009)01-0076-02ClinicalEvaluationofthreeMethodsintheTreatmentofKeloidGUOHai-xia,LIUGang,SHUAIHai-lin,JINGYa-sha(Department
3、ofPlasticSurgery,ChangzhengHospitalofTianjin,Tianjin300120,China)Abstract:ObjectiveToevaluatetheeffectofthreemethodsoftreatmentofkeloids:excisioncombinedwithpostoperativeradiation,excisioncombinedwithintralesionalinjectionofsteroidandintralesionalinjectionofsteroid.MethodsPatientswi
4、thkeloidsweredividedintogroupA,BandC・IngroupA,keloidswereremovedbyoperation,followedby90Sr-90Yirradiationoftotaldosesof900cGy,100〜200cGyofwhichwasappliedeveryotherday5timesacouseand2~3courseswouldberequiredtobecured・IngroupB,patientsweretreatedwithintralesionalinjectionof40mgtriamci
5、noloneduringandafteroperationexcision,whichwasrepeatedonce2weeks,4-8timesintota1.PatientsofgroupCweretreatedwithintralesionalinjectionofsingle40mgtriamcinoloneevery2weeks,8~12timesintotal.ResultsAfterrespectivetreatment,allpatientswerefollowedupfor24months・Theoverallefficacywas0.83%
6、,0.80%,and0.53%ingroupA,BandCrespectively.TherewassignificantdiffereneebetweengroupAandC(P<0.05),asisbetweengroupBandC.Conclusionitwasconcludedthattheeffectofthecombinedtherapyismoresatisfactorythanthatofasingleapproach・Keywords:keloid;operation;90Sr-90Yradiotherapy;triamcinolone对于瘢
7、痕疙瘩单一疗法往往疗效差、复发率高。我科自2003年2月〜2006年2月间,对60例瘢痕疙瘩患者进行手术切除后,辅以核素敷贴或局部注射糖皮质激素两种方法综合治疗,并与30例行单纯局部注射糖皮质激素治疗组进行疗效比较,显示综合治疗较单一治疗疗效满意,现报道如下。1资料和方法1.1临床资料:90例瘢痕疙瘩患者均来自我科门诊。随机分为A、B.C三组,每组30例,其中男27例,女63例,年龄12〜67岁,平均34.7岁。病程1〜23年。病变部位:耳垂39例,胸部27例,肩胛部15例,上臂5例,腹部12例。病灶共98处,最大12.3cmX3.8cm,最小2.lcmXO.
8、8cm。既往未经任何治疗者19例,其他