[精品]克罗恩病合并肛瘘综合治疗的临床分析

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1、克罗恩病合并肛痿综合治疗的临床分析克罗恩病合并肛痿综合治疗的临床分析［摘要］目的观察克罗恩病合并肛痿综合治疗的临床疗效。方法选取东阳人民医院2008年3月〜2013年3月收治的克罗恩病合并肛痿患者共108例，予综合治疗，观察患者肛门失禁情况、痿管的愈合时间、症状缓解情况及生物学指标，行2年随访观察手术后遗症发病情况。结果治疗后肛门失禁评分［(3.16±0.58)分］低于治疗前［(13.67±3.97)分］,差异有统计学意义(P〈0・05)；克罗恩病内镜严重程度指数［(2・03±0.54)分］、克罗恩病

2、简化活动指数［(139.86±34.29)分］、主观症状评分［(1.07±0.53)分］均优于治疗前［(7・89±2.34)、(287.04±95・45)、(2.36±0.75)分］,差异有统计学意义(P<0.05)；生物学相关指标均优于治疗前，差异有统计学意义(P〈0・05)；患者痿管愈合时间为(19.07±8.72)d；出现后遗症7例(6.48%)o结论克罗恩病合并肛痿采用综合治疗能够实现患者肛门功能的恢复与局部症状的减轻，效果理想，有临床应用价值。［关键词］克罗恩病；肛痿；综合治疗［中图分类号］

3、R574［文献标识码］A［文章编号］1673-7210(2014)10(b)-0035-04ClinicalanalysisofcomprehensivetreatmentofCrohndiseasecomplicatedwithanalfistulaCAIQiaoyinglYEFeng2A1・DongyangPeople，sHospital,ZhejiangProvince,Jinhua322109,China；2.TheFirstAffiliatedHospitalofZhejiangMedica

4、lUniversity,ZhejiangProvince,Hangzhou310003,China［Abstract］ObjectiveToobservetheclinicaleffectofcomprehensivetreatmentonanalfistulacomplicatedwithCrohndisease・MethodsFromMarch2008toMarch2013108patientswithCrohndiseasecomplicatedwithanalfistulaadmittedan

5、dtreatedinDongyangPeople，sHospitalwereselectedandgivencomprehensivetreatment.Analincontinence,healingtimeoffistula,remissionandbiologicalindicatorswereobservedandatwoyearlongfollow-upwasgiventoobservetheincidenceofsequelaeofoperation.ResultsAfterthetrea

6、tment,analincontinencescorewas(3.16+0.58)scores,significantlylowerthanbeforethetreatment(13・67±3.97)scores,thedifferencewasstatisticallysignificant(P<0.05)・ThescoresofCDEIS,CDAIandsubjectivesymptom[(2.03±0.54),(139.86+34.29),(1.07±0.53)scores],significa

7、ntlybetterthanthosebeforetreatment[(7.89±2.34),(287.04±95.45),(2.36±0.75)scores],thedifferenceswerestatisticallysignificant(P<0.05).Biologicalindexesweresignificantlybefterthanthosebeforetreatment,thedifferenceswerestatisticallysignificant(P<0.05)・Thehe

8、alingtimeoffistulaofthesepatientswas(19.07±8.72)dandtherewere7cases(6.48%)withseguelae・ConclusionComprehensivetreatment,inthetreatmentofanalfistulacomplicatedwithCrohndiseaseiseffectiveintherecoveryofanalfunctionanditlessensthelo